Immuno 3 Flashcards
Where does T-cell selection take place?
corticomedullary jxn
What cytokines do Th1 cells secrete?
IL-2, IFN-gamma
What cytokines do Th2 cells secrete?
IL-4, IL-5, IL-10
Function of IL-2
T-cell stimulator
Function of IFN-gamm?
MO stimulator
Function of IL-10?
Inhibites T-cell and MO
IL-4 and IL-5 function
B-cell stimulation
What cytokines enhance the activity of NK cells?
IL-2, IL-12, IFN-B, IFN-a
When are NK cells induced?
When there is an appropirate ratio of activation signals (exposed to nonspecific activation signal) and/or absence of class I MHC on target cell surface
Perforin and Granzyme are used by what cells to kill virally infected cells?
NK and cytotoxic T cells
What 2 signals do T cells need to become cytotoxic T cells?
- MHC I and TCR. 2. B7 (CD80 and CD86) and CD28
What 2 signals do T cells need to become CD4+ Th cells?
- TCR and MHC II. 2. B7 (CD86 and CD80) and CD28
What cells express CD16?
NK cells, MO, monocytes, neutrophils
What CDs do NK cells express?
CD16 and CD56
What do CD16 bind to? Function?
Bind fo constant region (Fc) on immunoglobulin. Recognize and kill immunoglobulin coated cells by antibody-dependent cell-mediated cytotoxicity (ADCC)
