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DIT > Immhno 6 > Flashcards

Immhno 6 Flashcards

1
Q

What is amyloidosis?

A

Abnormal aggregation of protiens into B-pleasted sheets that lead to cell damage/loss of function and apoptosis

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2
Q

What is the stain used to ID amyloid? What does it look like?

A

Congo red stain. Apple green birefringence under polarized light

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4
Q

ANA

A

SLE

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5
Q

Anti-dsDNA

A

renal disease in SLE

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6
Q

anti-Smith

A

SLE

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7
Q

Rheumatoid factor (IgM against IgG)

A

Screen for rheumatoid arthritis

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8
Q

anti-CCP

A

confirm RA

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9
Q

Anti-Scl-70 (aka anti-DNA topisomerase I)

A

Diffuse scleroderma

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10
Q

Antimitochondrial

A

1ry biliary cirrhosis

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11
Q

Anticentromere

A

CREST syndrome

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12
Q

IgA antiendomysial, IgA anti-tissue transglutaminase, anti-gliadin Ab

A

Celiac Disease

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13
Q

Anti-BM

A

Goodpasture’s syndrome

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14
Q

Anti-desmoglein

A

Pempigus vulgaris

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15
Q

Antimirosomal, antithyroglobulin

A

Hashimoto’s thyroditis

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16
Q

Anti-Jo-1, anti-SRP, anti-mi-2

A

Polymyositis, dermatomyositis

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17
Q

Anti-SSA (anti-Ro)

A

Sjorgen

18
Q

Anti-SSB (anti-La)

A

Sjorgen

19
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed CT disorder

20
Q

Anti-smooth muscle

A

Autoimmune hepatitis

21
Q

Anti-glutamate decarbozylase, anti-islet cell

A

Type I DM

22
Q

c-ANCA (PR3-ANCA)

A

Wegner’s granulomatosis (granulomatosis w/ polyangiitis)

23
Q

p-ANCA

A

Microscopic polyangiitis, Churg-Strauss syndrome

24
Q

MPO-ANCA

A

Pausi Immune Crescentric Glomerulonephritis

25
Q

Anti-Ach

A

Myasthenia gravis

26
Q

Anti-TSH receptor

A

Graves’

27
Q

What MUST be given with a killed virus vaccine?

A

Thymus-Dependent Antigen

28
Q

Thymus-independent antigens

A

Antigens lacking peptide component -> cannot be presented by MHC to T cells -> no immunologic memory (ex. LPS and capsular ag)

29
Q

Thymus-dependent antigens

A

Antigens containing protein component. Immunologic memory occurs as a result of direct B cells contact w/ Th cells (CD40-CD40L)

30
Q

Passive vs. Active immunity

A

FA 202

31
Q

What are examples of live attenuated vaccines?

A

Measles, mumps, polio (Sabin), rubella, varicella, yellow fever, intranasal influenza

32
Q

What are examples of inactivated/killed vaccines?

A

Cholera, hepatitis A, polio (Salk), rabies, IM influenza

33
Q

What are the egg-based vaccines?

A

Influenza, MMR (small amt), yellow fever

DIT (14 decks)

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