Immhno 6

Question 1

What is amyloidosis?

Answer 1

Abnormal aggregation of protiens into B-pleasted sheets that lead to cell damage/loss of function and apoptosis

Question 2

What is the stain used to ID amyloid? What does it look like?

Answer 2

Congo red stain. Apple green birefringence under polarized light

Question 4

ANA

Answer 4

SLE

Question 5

Anti-dsDNA

Answer 5

renal disease in SLE

Question 6

anti-Smith

Answer 6

SLE

Question 7

Rheumatoid factor (IgM against IgG)

Answer 7

Screen for rheumatoid arthritis

Question 8

anti-CCP

Answer 8

confirm RA

Question 9

Anti-Scl-70 (aka anti-DNA topisomerase I)

Answer 9

Diffuse scleroderma

Question 10

Antimitochondrial

Answer 10

1ry biliary cirrhosis

Question 11

Anticentromere

Answer 11

CREST syndrome

Question 12

IgA antiendomysial, IgA anti-tissue transglutaminase, anti-gliadin Ab

Answer 12

Celiac Disease

Question 13

Anti-BM

Answer 13

Goodpasture’s syndrome

Question 14

Anti-desmoglein

Answer 14

Pempigus vulgaris

Question 15

Antimirosomal, antithyroglobulin

Answer 15

Hashimoto’s thyroditis

Question 16

Anti-Jo-1, anti-SRP, anti-mi-2

Answer 16

Polymyositis, dermatomyositis

Question 17

Anti-SSA (anti-Ro)

Answer 17

Sjorgen

Question 18

Anti-SSB (anti-La)

Answer 18

Sjorgen

Question 19

Anti-U1 RNP (ribonucleoprotein)

Answer 19

Mixed CT disorder

Question 20

Anti-smooth muscle

Answer 20

Autoimmune hepatitis

Question 21

Anti-glutamate decarbozylase, anti-islet cell

Answer 21

Type I DM

Question 22

c-ANCA (PR3-ANCA)

Answer 22

Wegner’s granulomatosis (granulomatosis w/ polyangiitis)

Question 23

p-ANCA

Answer 23

Microscopic polyangiitis, Churg-Strauss syndrome

Question 24

MPO-ANCA

Answer 24

Pausi Immune Crescentric Glomerulonephritis

Question 25

Anti-Ach

Answer 25

Myasthenia gravis

Question 26

Anti-TSH receptor

Answer 26

Graves’

Question 27

What MUST be given with a killed virus vaccine?

Answer 27

Thymus-Dependent Antigen

Question 28

Thymus-independent antigens

Answer 28

Antigens lacking peptide component -> cannot be presented by MHC to T cells -> no immunologic memory (ex. LPS and capsular ag)

Question 29

Thymus-dependent antigens

Answer 29

Antigens containing protein component. Immunologic memory occurs as a result of direct B cells contact w/ Th cells (CD40-CD40L)

Question 30

Passive vs. Active immunity

Answer 30

FA 202

Question 31

What are examples of live attenuated vaccines?

Answer 31

Measles, mumps, polio (Sabin), rubella, varicella, yellow fever, intranasal influenza

Question 32

What are examples of inactivated/killed vaccines?

Answer 32

Cholera, hepatitis A, polio (Salk), rabies, IM influenza

Question 33

What are the egg-based vaccines?

Answer 33

Influenza, MMR (small amt), yellow fever