Endocrine 7

Question 1

Clinical uses of somatostatin?

Answer 1

1. Pituitary excess-acromegaly, TSH-secreting tumor, ACTH-secreting tumor. 2. GI endocrine excess-carcinoid syndrome, ZE syndrome, VIPoma, glucogonoma, insulinoma. Diarrhea. Dec splanchnic blood circ in pt w/ cirrhosis and esoph varices.

Question 2

Sx of hypothyroidism?

Answer 2

Cold intolerance (dec heat production), weight gain, dec appetitie, hypoactivity, lethargy, fatigue, weakness, constipation, dec reflexes, dry cool skin, coarse britle hair, bradycardia, dyspnea on exertion

Question 3

Lab findings of hypothyroidism?

Answer 3

Dec free T4 and inc TSH

Question 4

Causes of hypothyroidism?

Answer 4

1. Hashimoto thyroditis. 2. Cretinism. 3. Subacute thyroditis (de Quervain’s). 4. Riedel’s thyroditis.

Question 5

What is the most common cause of hypothyrodism?

Answer 5

Hashimoto thyroditis

Question 6

What is Hashimoto’s thyroiditis?

Answer 6

Autoimmune disorder (antithyroid peroxidase antibodies and antithyroglobulin antibodies).

Question 7

Hashimoto’s is assoc w what HLA?

Answer 7

HLADR5 and HLAB5

Question 8

Hashimoto’s histology?

Answer 8

Hurthle cells, lymphocytic infiltration w/ germinal centers (thyroid resembles lymph node)

Question 9

What cancer is Hashimoto’s at risk for?

Answer 9

Follicular B-cell lymphoma

Question 10

Presentation of Hashimoto’s?

Answer 10

Moderately enlarge, NONTENDER thyroid

Question 11

What could be an early finding of Hashimoto’s? Why?

Answer 11

Hyperthyroid due to destruction of thyroid follicle releasing thyroid hormones