Pharm

Question 1

Benzodiazepines

Answer 1

GABA-A (positive modulator)

Question 2

Buspirone

Answer 2

5-HT1A partial agonist

Question 3

Clonidine

Answer 3

Alpha-2 adrenoceptor agonist

Question 4

SSRIs

Answer 4

Serotonin reuptake transporter inhibition

Question 5

TCAs

Answer 5

Monoamine transporter (inhibition)- inhibiting reuptake of biogenic amines

Question 6

Haloperidol

Answer 6

Dopamine D2 antagonist

Acts on a G-protein coupled receptor

Question 7

Clozapine

Answer 7

Dopamine D3/D4 antagonist and 5-HT2A, alpha-1, H1 antagonist

Question 8

Phencyclidine

Answer 8

NMDA antagonist

Question 9

LSD

Answer 9

5-HT2A agonist

Question 10

Lithium

Answer 10

Exact mechanism not clear, may involve decreased responsiveness of phosphoinositol diphosphate second messenger syatem by blocking degradation and regeneration of inositol triphosphate

Question 11

Aripiprazole

Answer 11

D2 and 5HT-1a partial agonist and 5HT-2a antagonist

Question 12

Varenicline

Answer 12

Partial agonist A4B2 nicotinic receptor

Question 13

Cocaine

Answer 13

Dopamine reuptake inhibition

Question 14

Acamprosate

Answer 14

GABA agonist & glutamate antagonist

Question 15

Naltrexone

Answer 15

Mu opioid receptor antagonist

Question 16

Amphetamines

Answer 16

Catecholamine release (mostly dopamine) at the presynaptic terminal

Question 17

Valproic acid

Answer 17

Blocks voltage gated ion channels

Question 18

Pramipexole

Answer 18

Dopamine agonist

Question 19

Ramelteon

Answer 19

Melatonin agonist

Question 20

Caffeine

Answer 20

Antagonism of adenosine A2A receptor

Question 21

Stimulants and MAOIs require a 14 day washout T/F

Answer 21

T

Question 22

Appropriate action for a serum lithium level > 4.0 mEq/L

Answer 22

Haemodialysis

Question 23

Atomoxetine

Answer 23

Norepinephrine reuptake inhibitor