Neuroscience & Neuropsychiatry

Question 1

Where in brain is the greatest concentration of dopamine receptors?

Answer 1

Basal ganglia- caudate nucleus

Question 2

Area of brain affected by CO poisoning

Answer 2

Globus pallidus

Question 3

Where do cell bodies in the serotonergic system originate?

Answer 3

Brainstem raphe nucleus

Question 4

Caudates of ppl w OCD are smaller on imaging T/F

Answer 4

T

Question 5

The caudate undergoes significant degeneration in Huntington’s T/F

Answer 5

T

Question 6

Triphasic waves on EEG are synonymous with which pathology?

Answer 6

Hepatic encephalopathy

Question 7

The CGG trinucleotide repeat is found in which disorder?

Answer 7

Fragile X

Question 8

Atrophy of the parietal, temporal, and occipital lobes is most likely to be due to which disorder?

Answer 8

Alzheimer’s

Question 9

there is a larger brain mass in males compared to females T/F

Answer 9

T

Question 10

decreased GABA in Huntington’s chorea T/F

Answer 10

T

Question 11

antihistamines may cause psychosis T/F

Answer 11

T

Question 12

tardive dyskinesia can be voluntarily suppressed T/F

Answer 12

T

Question 13

Association with group A Beta-hemolytic streptococcal infection is required for a diagnosis of PANDAS T/F

Answer 13

T

Question 14

What is acalculia, agraphia, finger agnosia, and right-left disorientation called and what is it caused by?

Answer 14

Gerstmann syndrome - acalculia, agraphia, finger agnosia, and right-left disorientation
- caused by a lesion in the dominant parietal lobe

Question 15

Proportion of ppl with Parkinson’s disease with depression

Answer 15

depressive symptoms occur in approximately half of patients

with Parkinson’s disease

Question 16

Parkinson’s disease is a risk factor for the development of delirium T/F

Answer 16

T

Question 17

90% of ppl with REM behaviour disorder are male T/F

Answer 17

T

Question 18

The following is diagnostic of what: decreased REM latency on polysomnography (<15min)

Answer 18

Narcolepsy

Question 19

Treatment for REM sleep behaviour disorder

Answer 19

Clonazepam: 0.5mg-1mg 80-90% respond

+ Melan 6-15mg, lower numbers respond but worth trying first as it has better profile in terms of dependence risk

Question 20

Course of REM behaviour disorder

Answer 20

50% convert to parkinson’s in 10 years

Question 21

Delayed sleep phase disorder best treatment

Answer 21

Melatonin

Question 22

Hypocretin deficiency in CSF (<110pg/mL) is one of the diagnostic criteria for narcolepsy in DSM V T/F

Answer 22

T

Question 23

Which antidepressant doesn’t contribute to restless leg syndrome?

Answer 23

Wellbutrin

Question 24

Older adults need less sleep T/F

Answer 24

F

Question 25

Older adults have increased number of REM episodes T/F

Answer 25

T, it’s reduced REM overall and a pattern of fragmented shorter episodes of REM redistributed throughout the night

Question 26

Sleep in older adults is fragmented T/F

Answer 26

T

Question 27

There is a phase advance in sleep in the elderly T/F

Answer 27

T

Question 28

Slow wave sleep decreases in the elderly T/F

Answer 28

T

Question 29

Neurotransmitter responsible for REM sleep

Answer 29

Acetylcholine

Question 30

The diagnosis of Narcolepsy requires one of which of the following criteria, according to DSM V?

Answer 30

1. Cataplexy
2. Hypocretin deficiency
3. Nocturnal Sleep PSG showing REM latency of <=15 minutes or MSLT with mean sleep latency <=8 minutes + 2 or more sleep onset REM periods.

Question 31

Huntington’s is which chromosome?

Answer 31

Four, Huntington gene

Question 32

PANDAS is more common in boys T/F

Answer 32

T

Question 33

Complex partial seizures have strongly elevated suicide risk T/F

Answer 33

T

Question 34

Visuospatial deficits are seen with lesions of which hemisphere?

Answer 34

Right