personalised medicine: metabolism

Question 1

What are the two categories of drug metabolising enzymes?

Answer 1

1)catalytic eg ADH, G6PD 2)conjugative eg n-acetyl transferase

Question 2

What are cytochrome P450s?

Answer 2

phase 1 supergene family of enzymes

Question 3

what is phase 2 usually?

Answer 3

a conjugation reaction

Question 4

What is CYP2D6?

Answer 4

A cytochrome P450 enzyme

Question 5

When was CYP2D6 first identified?

Answer 5

in studies examining debrisoquine metabolism

Question 6

How many genetic variants does CYP2D6 have?

Answer 6

> 100, it is highly polymorphic

Question 7

What is a factor of homozygote CYP2D6?

Answer 7

poor metabolisers

Question 8

What is a factor of heterozygote CYP2D6?

Answer 8

immediate metabolisers

Question 9

What is a factor of gene duplication CYP2D6?

Answer 9

ultrarapid metabolisers

Question 10

What are 6 forms of CYP2D6 substrates?

Answer 10

1)antidepressants 2)beta blockers 3)antiphsychotics 4)antiarrhythmics 5)antihypertensives 6)codeine/phets

Question 11

What percentage of caucasians have the PM phenotype?

Answer 11

6-7

Question 12

Whom gets worst off ADR wise with CYP2D6?

Answer 12

PMs

Question 13

What do PMs mean for CYP2D6?

Answer 13

Cost more to treat, longer hospital stays