personalised medicine 1

Question 1

define personalised medicine

Answer 1

the concept that manageing a patients health should be based on the specific characteristics inc height weight gender diet environment etc

Question 2

define stratified medicine

Answer 2

therapies matched with specific patient population characteristics using clinical biomarkers

Question 3

define predictive medicine

Answer 3

rapidly emerging field of medicine that entails predicting disease and instituting preventative measures

Question 4

define theranostics

Answer 4

the term used to describe the proposed process of diagnostic therapy for individual patients

Question 5

define pharmacogenetics

Answer 5

study of clinical testing of genetic variation that gives rise to differing response to drugs

Question 6

pharmagogenomics?

Answer 6

effect of drugs on gene expression

Question 7

What are 6 points summing up personalised medicine?

Answer 7

1)treatment efficiacy in specific patients 2)determine optimal drug doses 3)ID patients who might have adverse drug reactions 4)assess extent or progression of disease 5)examine surrogate measures for clinical outcomes 6)ID patients who can benefit from specific preventative measures

Question 8

what are the two classes of genes associated with pharmacogenetics?

Answer 8

direct (eg gut receptors, carrier molecules and cell surface receptors) and indirect (gut architecture, competitor molecule expression and alternate pathways)

Question 9

Why study pharmacogenetics?

Answer 9

no/poor response and adverse drug reactions

Question 10

Give 4 examples of a poor response to a drug

Answer 10

1) decreased absorption 2)increased metabolism/reduced-prodrug activation 3)increased clearance 4)impaired receptor response

Question 11

Give 4 examples of an adverse drug reaction

Answer 11

1)increased absorption 2)accumumated toxic metabolites 3)reduced clearance 4)increased receptor response