personalised medicine: cancer

Question 1

give me three factoids about NON-MELANOMA skin cancer

Answer 1

1)more common with increasing age 2)BCCs are the most common skin cancer in palefaces 3)SCCs are the 2nd most

Question 2

BCC SCC?

Answer 2

Basal and squamous cell carcinomas

Question 3

The US and non-melanoma cancer?

Answer 3

skin cancer most common form of cancer in US, more peeps have had skin cancer in last 31 years than ALL OTHER CANCERS

Question 4

does NMSC metastasize?

Answer 4

nein

Question 5

nmsc mortality?

Answer 5

low

Question 6

nmsc in transplant patients?

Answer 6

increased incidence, more aggressive

Question 7

how often is nmsc screened for?

Answer 7

annually

Question 8

What is targeted surveillance:the predictive index?

Answer 8

generates a predictive index score that identifies high risk patients

Question 9

What does latitude have to do with clinical risk factors?

Answer 9

UV - the incidence of NMSC is much higher in RTR in hot countries than in those from temperate climates

Question 10

What does 4 UV exposures have to do with risk?

Answer 10

outdoor occupation, sunbathing, cumulative sun exposure, holidays abroad

Question 11

what adds to clinical risk factors host response wise?

Answer 11

male, skin type 1, blue/green eyes, red/blonde hair

Question 12

UV induced damage and clinical risk facotors?

Answer 12

premalignant lesions - keratoacanthoma bad - burning in childhood bad

Question 13

What two chemical exposures increase cancer risk?

Answer 13

smoking and arsenic

Question 14

4 genetic factors linked to cancer risk

Answer 14

1)melanisation 2)immune modulation 3)cell cycle control 4)UV induced oxidative stress

Question 15

What is the predictive index?

Answer 15

it combines risk factors to predict risk, using stepwise logistic regression to obtain the best set of predictors for developing NMSC withing x years - generated an index that ids high risk patients