Peripheral Circulation Flashcards
What is the relationship between pressure, flow, and resistance:
Flow = (PA-PV)/R
PA → arterial pressure
PV → venous pressure
R → resistance
Define: Autoregulation of Blood Flow
The intrinsic ability of an organ to maintain blood flow constant despite changes in perfusion pressure
as pressure increases, you get a proportional rise in resistance
What organs does autoregulation occur in?
Brain, Kidney, Heart
How does vascular smooth muscle respond to stretching?
by contracting (increasing resistance)
What range of pressures does autoregulation occur in?
between 60 - 140 mmHg
when pressure increases here, flow is maintained constant
Do endothelial cells influence autoregulation?
no
Define: Hyperemia
increased blood flow
Define: Active Hyperemia
During a period of increased metabolic rate (using a muscle), blood flow will increase to muscle being used during the period of metabolic activity and will stop when activity is stopped
What is responsible for active hyperemia?
metabolites
Define: Reactive hyperemia
increase in blood flow that occurs after a period of reduced or arrested blood flow
block blood flow and then restore causes increase in blood flow due to metabolites that build up
What does hyperemia depend on?
how long the blood flow was limited
What type of control predominates in the cardiovascular system?
local control over central control
What is the function of endothelial cells in vascular smooth muscle?
They function in the control of constriction and dilation
In the organ/tissue bath experiment, what happened before rubbing?
endothelial lining was intact
NE caused constriction
ACh caused relaxation
In the organ/tissue bath experiment, what happened after rubbing?
The endothelial layer was disrupted.
NE caused constriction
ACh also caused constriction
What is EDRF?
endothelium derived relaxing factor
Nitric Oxide released from endothelium to relax muscle
What can the endothelium release?
vasodilators and constrictors
Define: Endothelial Sheer Stress (ESS)
force caused by blood flowing past stationary cell on a vessel wall
changes at dif points in the vasculature
What part of the endothelial cell does ESS rapidly activate?
signal transduction and gene expression
How does ESS work?
endothelial cells can sense a change in sheer stress and it effects the gene expression in the cell
Define: Atherosclerosis
Beginning of is likely caused by ESS
can lead to blockage of coronary arteries and heart attacks
What influences the vascular smooth muscle?
endothelium and local tissue metabolites
How do NO and endothelin occur in a normal cell?
More Nitric Oxide than endothelin
How do NO and endothelin occur in a damaged cell?
more endothelin less nitric oxide
What does endothelial damage result in?
nicotine
HTN
aging
ischemia
Define: Humoral Mediators
circulating mediators that can effect vascular function
Humoral mediator → Vasodilators
Eicosanoids (Arachidonic acid) → PGI2, PGE 2, PGD 2
Atrial natriuretic peptide
Kinins (bradykinin)
Adenosine
Nitric Oxide → Endothlium-derived hyperpolarizing Factor (EDHF)
Histamine
Humoral Mediators → Vasoconstrictors
Eicosanoids (arachidonic acid) → TxA2, PGF2α, LTC4, LTD4, LTE4
What is the mechanism of membrane phospholipids?
Phospholipase A2 cleaves arachidonic acid from membrane phospholipid
Free arachidonic acid is added on by enzymes
CycloOxygenase can metabolize arachidonic acid and form prostoglandins