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Term 2 > Perio Ch 9, 5 > Flashcards

Perio Ch 9, 5 Flashcards

1
Q

The way that the body responds to periodontal pathogens is known as the??

A

Host response

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2
Q

What is the prime purpose of the human immune system?

A

To defend the life of the individual (host), not to preserve the tooth or its supporting periodontal tissues

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3
Q

Inflammatory mediators of importance in periodontal disease are?

A

Cytokines
Prostaglandins
Matrix meralloproteinases (MMPs)

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4
Q

______ Signal to the immune system to send more phagocytes to the site of infection

A

Cytokines

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5
Q

What cytokines are important in periodontal disease?

A

IL-1, IL-6, IL-8 and TNF-alpha

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6
Q

What can initiate tissue destruction and bone loss in chronic infections, such as periodontal disease?

A

Cytokines

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7
Q

What are powerful inflammatory mediators?

A

Prostaglandins

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8
Q

Which cells can produce prostaglandins?

A

Macrophages
PMNs
Gingival fibroblasts

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9
Q

Prostaglandins of the E series (PGE) initiate most of what?

A

The alveolar bone destruction in periodontitis

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10
Q

MMPs are produced by which various cells of the body?

A

PMNs
Macrophages
Fibroblasts
JE cells

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11
Q

In health, MMPs facilitate what?

A

Normal turnover of the periodontal connective tissue matrix

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12
Q

MMPs are released in attempt to what?

A

Kill invading bacteria

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13
Q

Over production of MMPs result in breakdown of what?

A

Connective tissue of the periodontium

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14
Q

High MMP levels result in what?

A

Extensive collagen destruction of periodontal tissues and without collagen the tissues of gingiva, PDL, and supporting alveolar bone degrade

Results in gingival recession, pocket formation and tooth mobility

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15
Q

T/F everyone who has periodontal pathogens will get periodontal disease?

A

FALSE

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16
Q

Over production of inflammatory mediators do what instead of being protective?

A

Destroys periodontal tissues

17
Q

Complex interactions between _____ and _____ determine the onset and severity of periodontal disease?

A

Periodontal pathogens and host response

18
Q

What are the phases of microscopic changed in periodontal disease?

A
  • early bacterial accumulation phase
  • early gingivitis (plaque over growth phase)
  • periodontitis (tissue destruction phase)
19
Q

T/F individuals with undiagnosed of uncontrolled diabetes are more likely to have periodontal disease than those without diabetes?

A

TRUE

20
Q

The rate of periodontal disease in diabetic patients is ___ times greater than in non diabetics

A

2-3

21
Q

The presence of periodontal pathogens alone is _____ to cause the tissue destruction seen in periodontitis?

A

Insufficient

Term 2 (21 decks)

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