Pathophysiology of thrombosis & embolism Flashcards
1
Q
What are some unusual conditions causing defects in blood flow?
A
Hyperviscosity, spasm,external compression,vasculitis and vascular steal
2
Q
What is a thrombus called outwith the vascular system?
A
-haemotoma
3
Q
How does a thrombus form due to a coronary artery plaque?
A
- Turbulent flow (fibrin deposition, platelet clumping)
- Loss of intimal cells, denuded plaque
- Collagen exposed, platelets adhere
- Fibrin meshaowrk traps RBC`s
4
Q
What are the lines of Zahn?
A
Fibrin mesh work with lines of cells
5
Q
What are the factors of Virchows triad?
A
- Stasis of blood flow
- Hypercoagulability
- Endothelial injury
6
Q
How many factors of Virchows triangle must you have before you get thrombosis?
A
2 factors
7
Q
When does turbulence cause thrombosis?
A
- Atheromatous plaque
- Aortic aneurysm
8
Q
What are the outcomes to thrombus?
A
- Resolution
- Organisation/recanalisation
- Propagation
- Death
9
Q
What is an embolism?
A
Movement of abnormal material in the bloodstream and its impact on a vessel and its lumen
