Pathology: outcome of inflammation Flashcards
what does outcome of inflammation dependent on
site of insult, type of insult and duration of insult
what are the outcomes of acute inflammation (4)
resolution, chronic inflammation, suppuration, organisation
describe what is meant by resolution of acute inflammation, and when would it occur
= restoration to normal function
occurs when; good blood supply, site has ability to renew(eg GI tract), source of injury is easily removed
what is supparation
= formation of pus, = a collection of fluid containing mix of inflammatory cells, bacteria or inflammatory products
when would organisation be a result of acute inflammation (4)
when there is; poor blood supply, extensive cell death + necrosis, a lot of fibrin been produced, tissue type has limited regenerative capacity
what can organisation of acute inflammation result in
facilitation of healing OR fibrosis + scarring
when would organisation result in facilitation of healing
if damage of a wound goes beyond the basement membrane
what happens when organisation occurs in form of facilitation of healing
formation of granulation tissue, formation of capillaries, delivery of myofibroblasts to lay down collagen + smooth muscle, and build scaffolding for healing
what happens when organisation occurs in form of fibrosis and scarring
= loss of function
neutrophils then macrophages then fibroblasts lay down collagen = scar tissue
what WBCs are involved in chronic inflammation
predominantly lymphocytes, macrophages also involved
what circumstances is chronic inflammation more likely to occur (4)
suppuration has produced walled off areas of pus, = abscess or empyema
infection is caused by virus or is persistent(eg TB)
injury is persistent, foreign body unable to be removed
aetiology is autoimmune
what can chronic inflammation produce
granulomas
caseous necrosis('cheesy'), eg in TBbriefly describe what granulomas produced by chronic inflammation are and give an example of a disease
= aggregate of epitheliod histiocytes or organised collection of macrophages
formed when immune system cannot eliminate perceived foreign material(ie parisitic infection)
example = sarcoidosis
