pathology exam 4

Question 1

what is PF attacking

Answer 1

desmoglein 1 that bridges the S. spinosum

Question 2

difference between PF and PVulgaris

Answer 2

PF has lesions higher up in the epidermis where PV has suprabasilar clefting

Question 3

intercellular edema

Answer 3

spongiosis

Question 4

intracellular edema

Answer 4

hydropic degeneration

Question 5

lesion seen in orf pox

Answer 5

ballooning degeneration/clefting

Question 6

two diseases that cause subepidermal clefting

Answer 6

MMP and bullous pemphigoid

Question 7

orthokeratosis vs parakeratosis

Answer 7

ortho is thickening of normal cells, parakaratosis is thickening of cornyeum but they retained their nuclei

Question 8

two dz that cause parakeratotic hyperkeratosis

Answer 8

zinc responsive dermatosis, superficial necrolytic dermatitis (NME)

Question 9

four diseases of the dermis

Answer 9

perivascular derm
nodular derm
lichenoid derm, interface derm

Question 10

ddx between interface derm and lichenoid derm

Answer 10

interface derm is primary keratinocyte necrosis.
luchenoid is inflammation without cell necrosis