drugs exam 4

Question 1

ideal drug characteristics for transdermal drugs

Answer 1

high concentration, low molecular weight, moderately lipophilic

Question 2

what are our two transdermal FDA drugs and who are they for

Answer 2

mirtazapine-cats, appetite stim
flunixin in beef cattle. BQA friendly analgesic.

Question 3

things to remember about fentanyl patches

Answer 3

do not cut, don’t put on incision, do not eat

Question 4

bonus about topical antimicrobials?

Answer 4

reach high [] at the site of action (the skin). sens testing isnt super reliable and drugs may still work if they say that they dont reach high[] in plasma

Question 5

5 topical antimicrobial

Answer 5

chlorhexidine, benzoyl peroxide, nitrofurans, mupirocin, silver sulfadiazine

Question 6

which topical is good for MRSA and MRSP

Answer 6

mupirocin

Question 7

which topical is prohibited in food animals

Answer 7

nitrofurans

Question 8

topical nonirritant, some fungal properties, great for burns

Answer 8

silver sulfadiazine

Question 9

otic formulation that is not ototoxic but includes pseudomonas

Answer 9

baytril otic

Question 10

topical that is ototox, gets pseudomonas and also antifungal

Answer 10

gent+mometasone+clotrimazole, mometamax

Question 11

otic not for pseudomonas, broad spec, w antifungal and steroid. not ototox

Answer 11

claro otic. florfenicol+terbinafine+mometasone

Question 12

first tier systemic antimicrobials

Answer 12

B-lactams: cephalexin, clauvamox
lincosamides: clindamycin
TMS

Question 13

last resort systemic antimicrobial

Answer 13

cephalosporins. cefpodoxime

Question 14

what does griseofulvin treat

Answer 14

ringworm only

Question 15

our two main antifungals systemic use. what is unique ab them

Answer 15

terbinafine and intraconazole. stay in skin for weeks after discontinuing

Question 16

common derm side effects of steroid use

Answer 16

thinning skin, folded ear tips, injection site rxn

Question 17

three main alts to GC or atopy/inflammation

Answer 17

cyclosporine, oclacitinib, lokivetmab

Question 18

common name for cyclosporine topical and systemic?

Answer 18

topical: optimmune
systsemic: atopica

Question 19

what are the FDA formulations of cyclosporine

Answer 19

microemulsions

Question 20

what drug can be given w cyclosporine to increase the [] of cyclosporine

Answer 20

ketoconazole

Question 21

what are our worries with giving cyclosporine for atopy

Answer 21

dont give to renal dz patients, neoplasia hx, gingival hyperplasia, no diabetic animals.

Question 22

oclactinib common name

Answer 22

apoquel

Question 23

what does oclacitinib do?

Answer 23

inhibit IL31 mediated pruritis

Question 24

what species can you use oclactinib (apoquel) in?

Answer 24

dogs, cats, and culiciodes hypersens in horses

Question 25

lokivetmab common name?

Answer 25

cytopoint

Question 26

what is unique about lokivetmab

Answer 26

monoclonal antibodies so very species specific and only give 1 every 4-8wks.

Question 27

where does lokivetmab go after absorption

Answer 27

to the lymphatic system