coma and seizures exam 2 Flashcards

1
Q

normal Intracranial pressure

A

5-10 mmHg

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2
Q

ICP regulation, what is altered first when trying to decrease pressure. what is second?

A

shunt CSF to the spinal subarachnoid space, then decrease csf production. finally decrease cerebral blood flow

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3
Q

decrease in cerebral blood flow is detremental to brain health. what happens if intracranial pressure is high while mean art BP is low.

A

mABP-ICP. if ICP is higher than mABP then the cerebral blood flow will be very low.

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4
Q

transtentorial herniations caudal and rostral cause what compression?

A

midbrain compression

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5
Q

which herniation has RAS system affected, cranial nerves IX-XII, and death

A

foramen magnum herniation. puts pressure on medulla

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6
Q

what is a clinically detrimental ICP?

A

greater than 30 mmHg will decrease cerebral blood flow

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7
Q

difference between decerebellate and decerebrate

A

decerebellate is opisthcontus with twisted torso, pelvic limbs flexed.

decerebrate: opisthcontus, extension of all four limbs, the fronts are rigid and the back are not flexed

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8
Q

what does the occulocephalic reflex test

A

interruption between vestibular and the nuclei because the CN for eye movement are not recieving messages from VIII

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9
Q

what do we try and treat in a TBI

A

secondary brain injuries. inflam, ischemia,

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10
Q

when do we do a CT:MRI on TBI patients

A

if we plan on doing surgery on the thing we find. if we dont plan on doing surgery, it really isnt indicated.

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11
Q

forebrain, midbrain, cerebellar, medulla. which are better prog than other areas for TBI

A

forebrain and cerebellar injury have better prog

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12
Q

SACS score of _____ has a 50% survival in first 48 ours

A

8

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13
Q

what is the first goal when treating a TBI

A

restoration of vital parameters. normovolemic, normotensive and ventilating. use what ever fluid you have.

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14
Q

goal 2 of treating TBI

A

after restoration of vitals, reduce ICP.

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15
Q

what pharma method is used to decrease ICP

A

mannitol diuretic.. draws water into circulation

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16
Q

what meds are commonly used to induce a coma

A

phenobarbital and NMDA agonists (ketamine)

17
Q

difference between reactive seizure ad epilepsy

A

reactive seizures are a response from a normal brain to a disturbance or toxin

epilepsy is a disease of the brain

18
Q

three types of epilepsy?

A

idiopathic structural and epilepsy of unknown cause

19
Q

what can occur in the pre-ictal period

A

prodrome; marked abnormal behavior days prior to the seizure (dog stops herding)
aura: abnormal sensation seconds prior to the seizure.

20
Q

what is the difference between syncope and a epileptic seizure

A

syncope lasts for seconds and is a sudden collapse. triggered by excitement

21
Q

how to differentiate epileptic seizure from narcolepsy

A

excitement stimulates narcolepsy, it is sudden collapse, can last minutes.

22
Q

myotonia, MG vs epilepsy

A

mytonia has a stiff gait, very long lasting, either stiff or flaccid collapse

23
Q

paroxysmal dyskinesia

A

episodic movement disorder from a gluten synstitvity. normal consciousness, hyper muscle tone.

24
Q

three ways we have reactive epileptic seizures

A

changes in resting membrane potential, too much excitation, too little inhibition

25
how does hyponatremia cause seizure
increase in NA compared to the environment out side of the cell. this changes the resting membrane potential, water follows sodium into the neuron, leading to axonal swelling
26
how does hypocalcemia cause seizure
less calcium means theres a dissociation from the Na channel. this makes the channels easier to open. more calcium moves into the cell changing the membrane potential
27
most reliable way to differentiate between structural epilepsy and idiopathic
structural occurs in less than 6mo and older than 6 years. there is usually drug resistance if you try and treat
28
most common chronic neurological disease in dogs?
idiopathic epilepsy (IE)
29
there are three tiers of Idiopathic epilepsy. what are the general characteristics needed to have tier one confidence level of IE
2 unprovoked seizures, known breed, normal tests between 6mo to 6years of age
30
tier 2 characteristics
normal pre and post bile acids, normal MRI, normal CSF,
31
tier 3s difference
EEG abnormalities
32
what are first line ASDs? for long acting drugs
phenobarbital and KBr, imepitoin is not used.
33
fast acting anti-seizure drugs
diazepam, midazolam, propofol
34
what is the theraputic ranges for phenobarbital
25-35.
35
superficial necrolytic dermatitis
chronic history of phenobarb administration 6 years. erosive dermatopathy, nonreversible. if you see skin lesions in your patient, do US an look for nodules.
36
there is only one FDA approved antiseizure drug. promidone. Why dont we use it
we do not use this because it is severely liver toxic.
37
what are the two uses for levetiracetam
add on med on top of daily med, and for structural epilepsy.