Pathology Ch 25 Skin

Question 1

What is the most common type of all autoimmune blistering disordering of the skin (pemphigus)?

Answer 1

Pemphigus Vulgaris(TOPNOTCH)

Question 2

Histologically, what is the most common denominator in all forms of pemphigus?

Answer 2

Acantholysis (TOPNOTCH)

Question 3

Morphology: Subepidermal nonacantholytic blisters

Answer 3

Bullous Pemphigoid (TOPNOTCH)

Question 4

Morphology: Suprabasal acantholytic blister

Answer 4

Pemphigus Vulgaris (TOPNOTCH)

Question 5

Morphology: Characteristically, fibrin and neutrophils accumulate selectively at the tips of the dermal papillae forming small microabscesses

Answer 5

Dermatitis Herpetiformis (Seen in Celiac Disease) (TOPNOTCH)

Question 6

Morphology: accumulation of neutrophils beneath the stratum corneum

Answer 6

Impetigo (TOPNOTCH)

Question 7

Munro microabscesses is classically seen in?

Answer 7

Psoriasis (TOPNOTCH)

Question 8

Auspitz sign is associated with what condition?

Answer 8

Psoriasis (TOPNOTCH)

Question 9

Pearly papules often containing prominent, dilated subepidermal blood vessels (telangiectasias)

Answer 9

Basal Cell Carcinoma (TOPNOTCH)

Question 10

What is the most commonly accepted exogenous cause of squamous cel carcinoma of the skin?

Answer 10

Exposure to UV light (TOPNOTCH)

Question 11

Cutaneous horns are seen in what condition?

Answer 11

Actinic Keratosis (TOPNOTCH)

Question 12

What factor is the most important in the determining the biological behavior of malignant melanoma? Vertical or Radial growth?

Answer 12

Vertical growth (TOPNOTCH)

Question 13

Morphology: characterized by loss of melanocytes

Answer 13

Albinism (TOPNOTCH)

Question 14

In albinism, melanocytes are present but melanin pigment is not produced due to what enzyme deficiency or defect?

Answer 14

Tyrosinase (TOPNOTCH)

Question 15

+ for melanocyte-associated proteins such as tyrosinase or Melan-A or S

Answer 15

Vitiligo (TOPNOTCH)

Question 16

The early developmental stage in melanocytic nevi is called?

Answer 16

Junctional nevi (TOPNOTCH)

Question 17

Most junctional nevi grow into the underlying dermis as nests or cords of cells and are calle

Answer 17

compound nevi (TOPNOTCH)

Question 18

When all the epidermal nests of compound nevi are lost entirely they form what

Answer 18

intradermal nevi (TOPNOTCH)

Question 19

Appears to play an important role in the development of skin malignant melanoma

Answer 19

Sunlight (TOPNOTCH)

Question 20

What are the 5 clinical warning signs of melanoma?

Answer 20

1. enlargement of a pre-existing mle
2. itching or pain in pre-existing mole
3. development of a new pigment lesion during adult life
4. irregularity of the borders of a pigment lesion
5. variegation of color within a pigmented lesion (TOPNOTCH)

Question 21

Morphology: proliferations of basaloid cells with formation of prominent keratin filled “horn” cysts

Answer 21

Seborrheic keratosis (TOPNOTCH)

Question 22

Appears clinically as flesh-colored, dome shaped nodules with central, keratin filled plug, imparting a crater like topography

Answer 22

Keratoacanthoma (TOPNOTCH)

Question 23

Morphology: Central, keratin filled crater surrounded by proliferating epitheal cells that extend upward in a lip-like fashion over the sides of the crater and downward into the dermis as irregular tongues

Answer 23

keratoacanthoma (TOPNOTCH)

Question 24

The most important clinical sign of malignant melanoma

Answer 24

change in color, size, or shape in a pigmented lesion (TOPNOTCH)

Question 25

In Malignant Melanoma, what type of growth indicated the tendency of a melanoma to grow horizontally within the epidermal and superficial dermal layers, often for a prolonged period of time?

Answer 25

Radial growth (TOPNOTCH)

Question 26

In Malignant Melanoma, what are the determinants of a more favorable prognosis?

Answer 26

1. Tumor depth of less than 1.7 mm
2. Absence or low numbers of mitoses
3. Presence of a brisk TIL response (Tumor Infiltrating Leukocytes)
4. Absence of regression
5. Female gender
6. Location on extremity skin (TOPNOTCH)