Pathology Ch 23 Breast

Question 1

Morphology: characterized chiefly by dilations of ducts, inspissation of breast secretions, and marked periductal and interstitial chronic granulomatous reaction

Answer 1

Mammary Duct Ectasia (TOPNOTCH)

Question 2

What are the 3 principal patterns of morphologic changes seen in Fibrocystic Changes of the breast?

Answer 2

1. Cyst formation with apocrine metaplasia
2. Fibrosis
3. Adenosis (TOPNOTCH)

Question 3

Morphology: “leaflike” architecture

Answer 3

Phyllodes Tumor (TOPNOTCH)

Question 4

Morphology: proliferation of intralobular stroma surrounding and often pushing and distorting the associated epithelium. The border is sharply delimited from the surrounding tissue

Answer 4

Fibroadenoma (TOPNOTCH)

Question 5

What is the most important prognostic factor useful as a predictive factor for the response of therapy in patients with breast cancer?

Answer 5

Presence of estrogen and progesterone receptors (TOPNOTCH)

Question 6

In breast cancer, what is the most important prognostic factor for invasive carcinoma in the absence of distant metastases?

Answer 6

Lymph node metastases (TOPNOTCH)

Question 7

Morphology: tumor cells are prsent as small clusters within large pools of mucin

Answer 7

Mucinous colloid carcinoma (TOPNOTCH)

Question 8

Morphology: characterized by solid syncytium like sheets occupying 75% of the tumor , prominent lymphoplasmacytic infiltrate and a non inflitrative border

Answer 8

Medullary carcinoma of the breast (TOPNOTCH)

Question 9

The histologic hallmark of this tumor is the pattern of single infiltrating tumor cells, often only one cell in width, or in loose clusters or sheets

Answer 9

Invasive lobular carcinoma (TOPNOTCH)

Question 10

This is a rare manifestation of breast cancer and presents as a unilateral erythematous eruption with a scale crust

Answer 10

Paget disease (TOPNOTCH)

Question 11

These are stellate lesions characterized by a central nidus of entrapped glands in a hyalinized stroma

Answer 11

Complex Sclerosing Lesion or Radial Scar (TOPNOTCH)

Question 12

Morphology: composed of multiple branching fibrovascular cores, each having a connective tissue axis lined by luminal and myoepithelial cells

Answer 12

Papillomas (TOPNOTCH)

Question 13

What is the most common clinical presentation of breast disease

Answer 13

Pain (TOPNOTCH)

Question 14

The principal mammographic signs of breast carcinoma

Answer 14

densities and calfications (TOPNOTCH)

Question 15

Morphology: the main histologic feature is keratinizing squamous epithelium extending to an abnormal depth into the orifices of the nipple ducts

Answer 15

Periductal mastitis (TOPNOTCH)

Question 16

Mammographic appearance: Large lobulated “popcorn” calcifications

Answer 16

Fibroadenoma (TOPNOTCH)

Question 17

Morphology: characterized by solid sheets of pleomorphic cells with high-grade nuclei and central necrosis detected mamographically as clusters or linear and branching microcalcifications

Answer 17

Comedocarcinoma (TOPNOTCH)

Question 18

Morphology: Terminal ducts (without lobule formation) are lined by a multilayered epithelium with small papillary tufts and surrounding periductal hyalinization and fibrosis.

Answer 18

Gynecomastia (TOPNOTCH)

Question 19

Morphology: terminal duct lobular unit is enlarged, and the acini are compressed and distorted within the lumens. Calcifications are often present within the lumens.

Answer 19

Sclerosing adenosis(TOPNOTCH)

Question 20

Morphology: central fibrovascular core extends from the wall of a duct. The papillae arborize within the lumen and are lined by myoepithelial and luminal cells

Answer 20

Intraductal papilloma(TOPNOTCH)

Question 21

Cellular proliferation resembling ductal carcinoma in situ or lobular carcinoma in situ but lacking sufficient qualitative or quantitative features for a diagnosis of carcinoma in situ

Answer 21

Atypical hyperplasia(TOPNOTCH)

Question 22

Refers to a proliferation of cells identical to those of LCIS but the cells do not fill or distend more than 50% of the acini within a lobule.

Answer 22

Atypical Lobular hyperplasia(TOPNOTCH)

Question 23

Recognized by its histologic resemblance to ductal carcinoma in situ, including a monomorphic cell population, regular cell placement, and round lumina. However, the lesions are characteristically limited in extend, and the cells are not completely monomorphic in type or they fail to completely fill ductal spaces

Answer 23

Atypical hyperplasia(TOPNOTCH)

Question 24

What are the two major risk factors for breast carcinoma?

Answer 24

Hormonal and Genetics/family history(TOPNOTCH)

Question 25

This is a subtype of DCIS which is recognized by bulbous protrusions without a fibrovascular core, often forming complex intraductal patents.

Answer 25

Micropapillary DCIS(TOPNOTCH)

Question 26

This is a subtype of DCIS which is recognized by bulbous protrusions without a fibrovascular core, often forming complex intraductal patents.

Answer 26

Micropapillary DCIS(TOPNOTCH)

Question 27

This is a subtype of DCIS which is recognized by bulbous protrusions without a fibrovascular core, often forming complex intraductal patents.

Answer 27

Micropapillary DCIS(TOPNOTCH)