Pathology Ch 23 Breast Flashcards
Morphology: characterized chiefly by dilations of ducts, inspissation of breast secretions, and marked periductal and interstitial chronic granulomatous reaction
Mammary Duct Ectasia (TOPNOTCH)
What are the 3 principal patterns of morphologic changes seen in Fibrocystic Changes of the breast?
- Cyst formation with apocrine metaplasia
- Fibrosis
- Adenosis (TOPNOTCH)
Morphology: “leaflike” architecture
Phyllodes Tumor (TOPNOTCH)
Morphology: proliferation of intralobular stroma surrounding and often pushing and distorting the associated epithelium. The border is sharply delimited from the surrounding tissue
Fibroadenoma (TOPNOTCH)
What is the most important prognostic factor useful as a predictive factor for the response of therapy in patients with breast cancer?
Presence of estrogen and progesterone receptors (TOPNOTCH)
In breast cancer, what is the most important prognostic factor for invasive carcinoma in the absence of distant metastases?
Lymph node metastases (TOPNOTCH)
Morphology: tumor cells are prsent as small clusters within large pools of mucin
Mucinous colloid carcinoma (TOPNOTCH)
Morphology: characterized by solid syncytium like sheets occupying 75% of the tumor , prominent lymphoplasmacytic infiltrate and a non inflitrative border
Medullary carcinoma of the breast (TOPNOTCH)
The histologic hallmark of this tumor is the pattern of single infiltrating tumor cells, often only one cell in width, or in loose clusters or sheets
Invasive lobular carcinoma (TOPNOTCH)
This is a rare manifestation of breast cancer and presents as a unilateral erythematous eruption with a scale crust
Paget disease (TOPNOTCH)
These are stellate lesions characterized by a central nidus of entrapped glands in a hyalinized stroma
Complex Sclerosing Lesion or Radial Scar (TOPNOTCH)
Morphology: composed of multiple branching fibrovascular cores, each having a connective tissue axis lined by luminal and myoepithelial cells
Papillomas (TOPNOTCH)
What is the most common clinical presentation of breast disease
Pain (TOPNOTCH)
The principal mammographic signs of breast carcinoma
densities and calfications (TOPNOTCH)
Morphology: the main histologic feature is keratinizing squamous epithelium extending to an abnormal depth into the orifices of the nipple ducts
Periductal mastitis (TOPNOTCH)
Mammographic appearance: Large lobulated “popcorn” calcifications
Fibroadenoma (TOPNOTCH)
Morphology: characterized by solid sheets of pleomorphic cells with high-grade nuclei and central necrosis detected mamographically as clusters or linear and branching microcalcifications
Comedocarcinoma (TOPNOTCH)
Morphology: Terminal ducts (without lobule formation) are lined by a multilayered epithelium with small papillary tufts and surrounding periductal hyalinization and fibrosis.
Gynecomastia (TOPNOTCH)
Morphology: terminal duct lobular unit is enlarged, and the acini are compressed and distorted within the lumens. Calcifications are often present within the lumens.
Sclerosing adenosis(TOPNOTCH)
Morphology: central fibrovascular core extends from the wall of a duct. The papillae arborize within the lumen and are lined by myoepithelial and luminal cells
Intraductal papilloma(TOPNOTCH)
Cellular proliferation resembling ductal carcinoma in situ or lobular carcinoma in situ but lacking sufficient qualitative or quantitative features for a diagnosis of carcinoma in situ
Atypical hyperplasia(TOPNOTCH)
Refers to a proliferation of cells identical to those of LCIS but the cells do not fill or distend more than 50% of the acini within a lobule.
Atypical Lobular hyperplasia(TOPNOTCH)
Recognized by its histologic resemblance to ductal carcinoma in situ, including a monomorphic cell population, regular cell placement, and round lumina. However, the lesions are characteristically limited in extend, and the cells are not completely monomorphic in type or they fail to completely fill ductal spaces
Atypical hyperplasia(TOPNOTCH)
What are the two major risk factors for breast carcinoma?
Hormonal and Genetics/family history(TOPNOTCH)
