Pathology Flashcards
The exception to the rule that pathologic hyperplasia can lead to dysplasia cancer.
BPH: benign prostatic hyperplasia
Major cellular mechanism of cellular hypertrophy
Protein synthesis, gene activation and production of organelles (cytoskeleton, mitochondria)
Permnent tissues cannot undergo hyperplasia or hypertrophy. What are the 3 examples of permanent tissue in the body?
Hyperplasia
- Cardiac muscle
- Skeletal muscle
- Nerve
Classical example of pathologic hyperplasia leading to dysplasia and cancer (female)
Endometrial hyperplasia
Mechanism of atrophy (2)
- Apoptosis (decrease number of cells)
2. Ubiqiquitin-proteasome degradation of cytoskeleton; autophagy (cell size)
Metaplasia most often involves what body surfaces
Surface epithelium
Classical example of metaplasia (GIT)
Barret’s esophagus (squamous–> columnar w/ goblet cells)
What is the mechanism of metaplasia? Is it reversible?
Reprogramming of stem cells; yes
What is the exception to the rule that metaplasia can progress to dysplasia and cancer (female).
Apocrine metaplasia (Fibrocystic change of the breast)
Deficiency of what vitamin can lead to metaplasia, i.e. keratomalacia?
Vitamin A: keratomalacia
t(15, 17) translocation
APML (cells trapped in blast)
* Treatment with ATRA
Mesenchymal tissues can undergo metaplasia. The classical example is:
Myositis ossificans; caused by trauma
(Metaplastic production of bone in the skeletal muscle); look for ossificatiion within the skeletal muscle. This is not an osteosarcoma b/c there is distinct separation
How do you differentiate between osteosarcoma and myositis ossificans on an X-ray?
OS: part of bone
MO: distinct separation of bone from muscle
3 uses of vitamin A in the body
- Night blindness
- Immuno cells
- Specialized epithelium
T/F Dysplasia is reversible
True
Aplasia; classical example
Failure of cellular production during embryogenesis
Hypoplasia; classical example
Decrease in cell production during embryogenesis
Streak ovary in Turner Syndrome
Cell injury occurs when stress ___________
Exceeds a cell’s ability to adapt; type of stress, severity, type of cell affected
Slow progressive decrease in blood supply to the kidney results in _________; whereas a rapid decrease in blood supply results in _______
- Atrophy
2. Infarction
T/F Neurons are very susceptible to hypoxia.
True
Common causes of cellular injury
Inflammation, nutritional deficiency/excess, hypoxia, trauma, genetic mutations
Define hypoxia
Low oxygen delivery to tissue; low ATP; cellular injury
The 3 major causes of hypoxia
- Ischemia
- Hypoxemia
- Decreased O2 carrying capacity of the blood
Define ischemia. Through what 3 mechanisms can ischemia occur?
Decreased blood flow through an organ;
- Arterial flow blockage (atherosclerosis)
- venous outflow obstruction
- Shock (heart, hypovolemic, neurogenic, septic, anaphylactic)