patho. haemostasis

Question 1

Which is involved in the final phase of blood clotting?

Answer 1

formation of fibrin

Question 2

most common bleeding disorder? other types?

Answer 2

Von Willebrand
> generally less severe than haemophilia.

Of the two types of haemophilia, haemophilia A is more common than B, however both types are relatively rare.

Question 3

What is this enzyme cyclooxygenase 1 (COX-1) responsible for?

Answer 3

formation of thromboxane A2.

>chemical mediator is a platelet activator released by activated platelets.

Question 4

platelet activator examples

Answer 4

cyclooxygenase 1 (COX-1)

ADP

> platelets can aggravate and clot

Question 5

The conversion of prothrombin to thrombin is done by ?

Answer 5

factor X in the clotting cascade.

Question 6

what is affected in a patient with low platelets?

Answer 6

bleeding time

none of the other times as these measure the clotting factors not platelets

Question 7

list anticoagulants.

risk of an inherited mutation of these?

Answer 7

Protein S
protein C
antithrombin III.

control the clotting cascade.

> a deficiency in this anticoagulant due to an inherited gene mutation are at… higher risk of developing blood clots!!

Question 8

what is DIC?

Answer 8

DIC is a pathological activation of the clotting cascade, causes micro-thrombi clots to form.

Question 9

haemophilia A caused by a deficiency in..?

Answer 9

factor 8

Question 10

which blood test would be. raised in a patient with pulmonary embolism after DVT?

Answer 10

D dimer

body responds by activation fibrinolytic system to break down the clot/ fibrin> into D dimer