Path of Immunity 5 AIDS/Amyloid Flashcards
AIDS (full name)
AIDS vs HIV?
3
AIDS
started?
first affected? would see what?
type of virus?
how does HIV spread?
who is at risk?
sexual transmission
Forms that are highly likely to spread virus?
one form less so?
what introduces virus into bloodstream? (previous step) also gets infected?
synergy of HIV and non-HIV STD’s?
other transmission routes
parenteral routes include? 2 more common one?
how in transfusions if we test them?
mother to child how? 3
risk of seroconversion (what is this?) after a needlestick accident?
HIV? Hep C?
HIV type of virus?
which family?
these type of viruses work how?
HIV-1 structure and content
capsid proteins? good for?
glycoproteins? 2 good for?
viral enzymes? 3
HIV-1 RNA genome? 4
HIV-1 regions to know
4
what do each encode for?
HIV life cycle
virus entry- what receptor is used? co receptor? which ligand binds to this receptor? (location of ligand/receptor) after binding what allows entering the cell? what enters cell?
HIV life cycle
Virus replication- enzyme that puts into DS DNA? what inserts into host genome?
this causes what to happen?
activation occurs wen what happens?
Virus replication HIV
2nd part antigenic stimulation causes release of?
what is it supposed to do? what does it actually do?
Virus release HIV
responsible for the host cell death? this is called?
other mechanism of cell death described?
HIB tropism allows for?
which ones? 3 can cause?
prefers what? what doesnt occur here?
B lymphocytes in HIV infection
what happens? due to?
this can cause what to happen?
disease can be present?
impaired? what is reduced?
pathogenesis of HIV infection
what increases rate of viral entry? cells transport virus? to where? what occurs here?
pathogenesis of HIV infection pt 2
at 2-3 weeks?
3-7?
can be years?
HIV viremia happens when? what happens here?
seroconversion happens when? this causes what to happen? symptoms?
testing HIV
whats the first 3 things detectable in order?
days?
window period important because of?
dontated blood and blood products are tested for HIV with? window period?
HIV
acute retroviral syndrome- what do you see?
what happens during this time? (red circle)
what drops after acute?why?
HIV what is the viral set point?
this may predict what?
clinical latency is? last how long?
what usher in the diagnosis of AIDS?
3
what is a low CD4?
HIV/AIDS 2019
HIV diganosis made early- what treatment?
manifestations of AIDS occur first- 2?
what is shown here?
what interesting infection can point towards HIV infection?
AIDS defining illness? can be what?
how does it look radiographically?
histo
Diarrhea in AIDS patients?
caused by?
water supply?
what is this? name?
why is it odd?
associated with development of this tumor?
AIDS-related lymphomas
2?
spectrum of AIDS-related lymphomas
3
One last AIDS-defining illness cancer?
2
can be in concert with?
Co-infection important why?
AIDS the outlook
death now?
controlled?
started as?
Amyloidosis
protein synthesis and secretion is normally?
if mutations or bad processing what occurs? this yields what?
then leads to?
type of stain?
what is shown with stain?
amyloid
2 types? (locations)
l- what is causing it?
s- types? (type of problem) accumulate where?
acquired or hereditary?
chemical properties?
production of abnormal amounts of protein
acquired- type of cell? leads to? type of protein?
chronic inflammation- type of cells ? leads to? type of protein?
production of normal amount of protein
mutation- leads to? type of protein?
why AL?
why AA?
which is chronic?
where does amyloid tend to manifest?
color you see?
if systemic where can you try to diagnose and biopsy?
if amyloid in kidney leads to what? special about this?
if in the heart? lead to? special about this?
what confirms bubble gum amyloidosis?
picture below is under what condition?
