Path of Immunity 5 AIDS/Amyloid

Question 1

AIDS (full name)

AIDS vs HIV?

3

Answer 1

Question 2

AIDS

started?

first affected? would see what?

type of virus?

Answer 2

Question 3

how does HIV spread?

who is at risk?

Answer 3

Question 4

sexual transmission

Forms that are highly likely to spread virus?

one form less so?

what introduces virus into bloodstream? (previous step) also gets infected?

synergy of HIV and non-HIV STD’s?

Answer 4

Question 5

other transmission routes

parenteral routes include? 2 more common one?

how in transfusions if we test them?

mother to child how? 3

Answer 5

Question 6

risk of seroconversion (what is this?) after a needlestick accident?

HIV? Hep C?

Answer 6

Question 7

HIV type of virus?

which family?

these type of viruses work how?

Answer 7

Question 8

HIV-1 structure and content

capsid proteins? good for?

glycoproteins? 2 good for?

viral enzymes? 3

HIV-1 RNA genome? 4

Answer 8

Question 9

HIV-1 regions to know

4

what do each encode for?

Answer 9

Question 10

HIV life cycle

virus entry- what receptor is used? co receptor? which ligand binds to this receptor? (location of ligand/receptor) after binding what allows entering the cell? what enters cell?

Answer 10

Question 11

HIV life cycle

Virus replication- enzyme that puts into DS DNA? what inserts into host genome?

this causes what to happen?

activation occurs wen what happens?

Answer 11

Question 12

Virus replication HIV

2nd part antigenic stimulation causes release of?

what is it supposed to do? what does it actually do?

Answer 12

Question 13

Virus release HIV

responsible for the host cell death? this is called?

other mechanism of cell death described?

Answer 13

Question 14

HIB tropism allows for?

which ones? 3 can cause?

prefers what? what doesnt occur here?

Answer 14

Question 15

B lymphocytes in HIV infection

what happens? due to?

this can cause what to happen?

disease can be present?

impaired? what is reduced?

Answer 15

Question 16

pathogenesis of HIV infection

what increases rate of viral entry? cells transport virus? to where? what occurs here?

Answer 16

Question 17

pathogenesis of HIV infection pt 2

at 2-3 weeks?

3-7?

can be years?

Answer 17

Question 18

HIV viremia happens when? what happens here?

seroconversion happens when? this causes what to happen? symptoms?

Answer 18

Question 19

testing HIV

whats the first 3 things detectable in order?

days?

window period important because of?

Answer 19

Question 20

dontated blood and blood products are tested for HIV with? window period?

Answer 20

Question 21

HIV

acute retroviral syndrome- what do you see?

what happens during this time? (red circle)

what drops after acute?why?

Answer 21

Question 22

HIV what is the viral set point?

this may predict what?

clinical latency is? last how long?

Answer 22

Question 23

what usher in the diagnosis of AIDS?

3

what is a low CD4?

Answer 23

Question 24

HIV/AIDS 2019

HIV diganosis made early- what treatment?

manifestations of AIDS occur first- 2?

Answer 24

Question 25

what is shown here?

Answer 25

Question 26

what interesting infection can point towards HIV infection?

Answer 26

Question 27

AIDS defining illness? can be what? how does it look radiographically? histo

Answer 27

Question 28

Diarrhea in AIDS patients? caused by? water supply?

Answer 28

Question 29

what is this? name? why is it odd? associated with development of this tumor?

Answer 29

Question 30

AIDS-related lymphomas 2?

Answer 30

Question 31

spectrum of AIDS-related lymphomas 3

Answer 31

Question 32

One last AIDS-defining illness cancer? 2 can be in concert with? Co-infection important why?

Answer 32

Question 33

AIDS the outlook death now? controlled? started as?

Answer 33

Question 34

Amyloidosis protein synthesis and secretion is normally? if mutations or bad processing what occurs? this yields what? then leads to?

Answer 34

Question 35

type of stain? what is shown with stain?

Answer 35

Question 36

amyloid 2 types? (locations) l- what is causing it? s- types? (type of problem) accumulate where? acquired or hereditary? chemical properties?

Answer 36

Question 37

production of abnormal amounts of protein acquired- type of cell? leads to? type of protein? chronic inflammation- type of cells ? leads to? type of protein? production of normal amount of protein mutation- leads to? type of protein?

Answer 37

Question 38

why AL? why AA? which is chronic?

Answer 38

Question 39

where does amyloid tend to manifest? color you see? if systemic where can you try to diagnose and biopsy?

Answer 39

Question 40

if amyloid in kidney leads to what? special about this? if in the heart? lead to? special about this?

Answer 40

Question 41

what confirms bubble gum amyloidosis? picture below is under what condition?

Answer 41