Path of Immunity 3 Autoimmune Diseases Flashcards
autoimmune disease conditions?
immunologic tolerance
type of tolerance?
what is each?
central tolerance
locations? cells?
fate?
peripheral tolerance outcomes?
anergy:
what is it? mediated by what receptors?
these will do what?
tumors and viruses?
tumor immunotherapy via anergy
what is the therapy? result?
peripheral tolerance: Treg cell suppression
type of tregs? 3
actions include? cytokines?
WHAT IS THE MAJOR PLAYER FOR TREG?
4 mechanisms of peripheral self-tolerance?
murphy’s law path?
2 genes?
leads to what?
what is an autoimmune disease?
what three players for autoimmune disease?
specifics?
Mechanisms
susceptibility genes leads to?
epitope spreading?
diseases?
Hereditary inflammatory condition of joints?
particularly where?
inflammation leads to?
associated with what? (genetically)
if you have this gene do you have this disease?
Crohn Disease
polymorphism in? this causes? what particular cells?
result of that goes to?
mechanism of why you cant kill?
what do you see anatomically?
oral lichen planus and _______ _____
what happens?
autoimmune diseases?
4
which ones are ANA? this stands for?
other examples not talked about in detail in this lecture?
ANA tests for?
presence prompt what?
if negative?
for the 3 positive for ANA what are the more specific tests you would order?
Systemic lupus erythematosus
associated with? what factors for disease?
genetic association? gender bias? what other trigger?
immune mechanisms involved?
SLE
criterion?
2 big ones? 10 total
when do you start to expect lupus?
6
the most prevalent in patients?
one that stems from somewhere else?
Lupus nephritis steps
what should you know? first last middle?
most common pattern of lupus nephritis called?
symptoms?
histo? 2
diffuse lupus nephritis immunoflouresence stain?
type of pattern?
this means?
Skin and SLE
what happens?
positive for? pattern?
what do you see?
malar or butterfly
cardiovascular complications of lupus?
2
what are they? made up of? contribution form? at risk for?
what is this?
lupus
variants of lupus just name both this the one that would be found earlier in dictionary
what are the symptoms?
discoid lupus
what areas affected? tests positive/negative?
progression?
2nd variation of lupus?
symptoms present?
Drug-induced lupus
what is it? 2 meds?
tests positive? negative?
resolves with?
HLA high-risk linkages?
autoimmune disease resulting in destruction of lacrimal and salivary gland tissue?
mechanism? how does damage occur?
what do you see grossly? histologically?
other gross symptoms of Sjogren syndrome
3 caused by? causes?
Sjogren syndrome
clinical presentation?
dignostic tests? 3
compications? 2
another name for scleroderma?
what is it?
locations?
limited form where?
can be part of what syndrome?
pathology of systemic sclerosis
what will you see?
what can get compromised?
what can you see in systemic sclerosis grossly?
other manifestations of systemic sclerosis
3 main areas? problems with these areas?
what tests with these ANA for what disease?
what is CREST syndrome?
better or worse than original?
what symptoms seen?
what is mixed connective tissue disease?
test?
common feature?
IgG4-related disease
what is it?
what is present in IgG4 pathophsy?
2 type of cells leading to what type of damage?
stain?
IgG4
can see what in what systems? histo?
