Path of Immunity 4 Transplant Rejection/Immunodeficiency Syndromes

Question 1

transplant rejection

allorecognition?

rejection types? 2 main?

organ specific? organs

Answer 1

Question 2

allorecognition

two pathways?

difference?

Answer 2

Question 3

timing of rejection

depends on?

different timings?

which are b-cell? t-cell?

Answer 3

Question 4

hyperacute rejection

timing?

mediated by? mainly?

what do you see?

Answer 4

Question 5

acute and chronic antibody-mediated rejection

timing?

acute: what do you see? what product?

what would be positive?

chronic: what would you see?

Answer 5

Question 6

acute cellular rejection

mediated by?

timing?

how do you tell the difference between this and antibody-mediated rejection?

Answer 6

Question 7

why do we care about difference between antibody mediated and acute cellular?

what are they?

Answer 7

Question 8

when you treat for rejection what happens?

good?

bad? (2) specific example for one?

Answer 8

Question 9

hematopoietic stem cell transplant aka?

therapy for?

ablative chemo does what?

then do what?

will you reject the new bone marrow?

Answer 9

Question 10

graft versus host disease

mediated by?

skin? liver? intestines?

Answer 10

Question 11

immunodeficiency syndromes

primary?

secondary?

Answer 11

probably easiest to know secondary and be able to recognize the others

Question 12

Answer 12

Question 13

Answer 13

Question 14

chediak higashi syndrome

rare? inheritance?

what is wrong? causes? outlook?

test?

Answer 14

Question 15

what are these?

what else phenotype can you see in this disease?

Answer 15

Question 16

chronic granulomatous disease

problem here?

what forms? made of?

Answer 16

Question 17

Answer 17

Question 18

MAC deficiency

what components can be affected?

without MAC what happens?

common infections?

Answer 18

Question 19

hereditary angioedema

inheritance?

problem here?

immunodeficiency?

symptoms

Answer 19

Question 20

symptoms of hereditary angioedema

Answer 20

Question 21

Answer 21

Question 22

primary adaptive immunodeficiency syndromes

chart

more severe at beginning or end of maturation?

Answer 22

Question 23

SCID

forms? common theme?

1. more common in? mutation where? B cell affected how?
2. inheritance? problem here? what happens?

Answer 23

Question 24

SCID treatment

Answer 24

Question 25

DiGeorge syndrome

what is wrong? (tissue areas affected?)

inheritance?

many cases are related to?

Answer 25

Question 26

DiGeorge syndrome manifestations

4

can be part of what disease? how?

Answer 26

Question 27

X-linked agammaglobulinemia aka?

whats the problem?

at risk for? when?

Answer 27

Question 28

presentation of agammaglobulinemia

what do you see? 3 examples?

Answer 28

Question 29

Answer 29

Question 30

hyper-IgM syndrome

what predominates?

due to?

whats wrong?

Answer 30

Question 31

Hyper-IgM syndrome

mutations where? this fucks up what?

increased levels of? low?

treat with? 2

Answer 31

Question 32

most common significant primary immunodeficiency?

multiple disorders? results in?

presentation?

disease of?

presentation?

Answer 32

Question 33

CVID

presentation

4

1. specific

2.

3. specific

4 specific (2)

Answer 33

Question 34

IgA deficiency (isolated)

inheritance?

loss of IgA means? results in? 5

Answer 34

Question 35

possible first indication of IgA deficiency?

what happens?

prevent how?

Answer 35

Question 36

Answer 36

Question 37

Wiskott aldrich syndrome

presentation?

caused by?

treatment? lack of treatment?

Answer 37

Question 38

Ataxia Telangiectasia

type of disease?

you can see what clinically?

immune deficiency?

inheritance? gene?

Answer 38

Question 39

secondary immunodeficiency can be seen in what clinical situations?

big one?

Answer 39