Disease of Infancy and Childhood 3 Tumors and Tumor-like Lesions

Question 1

Tumors/tumor-like lesions

malignant tumor common children? but?

Two categories of tumor-like lesions distinguished from true tumors

Answer 1

Question 2

Benign tumors and tumor-like lesions

4 we care about here?

most common neoplasm? children/adults?

Answer 2

Question 3

most common tumor of infancy?

type of hemangiomas encountered? located where? another term for flat large lesion? growth?

can be part of what disorder?

familial?

Answer 3

Question 4

lymphatic tumor

lymphatic origin? while others? often occur where?

growth? can cause?

lymphangiectasis in contrst?

Answer 4

Question 5

fibrous tumors

range?

apposed to adult ones?

gene?

Answer 5

Question 6

Teratomas

what are they? can be what type of lesion?

most common teratoma of childhood?

peak in incidence?

malignant potential correlates with?

Answer 6

Question 7

malignant tumors

main differences with childhood cancer?

Answer 7

Question 8

incidence and types

most frequent arise in what system? compared to adults? under 10 increased incidence of what cancers?

most leathal?

histo- cells look like what? naming?

some ex?

Answer 8

Question 9

common malignant neoplasms by age

0-4 5-9 10-14

Answer 9

Question 10

Neoblastic tumors

include what? (def)

most important member of this family? incidence?

mutations? familial?

high risk survival? prognosis better for who?

Answer 10

Question 11

Neuroblastomas morph

arsie mainly where? size?

capsule? how does tissues look?

histo- cells?

background? rosettes?

Answer 11

Question 12

what is a ganglioneuroma?

type of cells you should see?

what do you see that is favorable?

spread to?

staging? what does each entail?

most present with?

Answer 12

Question 13

prognostic factors in neuroblastoma

Answer 13

Question 14

neuroblastoma clin course prognostic features

under 2 present with? metastasize where?

paraspinal has?

skin?

produce what? diagnostic?

risks?

long term survival?

Answer 14

Question 15

Neuroblastoma prognostic factors

stage- normal good prognosis? exception?

age- normal good? high risk?

morphology-

Answer 15

Question 16

neuroblastoma prognostic factors

what oncogene very important? chromo?

ploidy- important for what age? 2 types? better of two?

aggressive neuroblastoma is called? involves what damage?

Answer 16

Question 17

Neuroblastoma. other molecular variables

3

Answer 17

Question 18

neuroblastoma

2 experimental approaches to treatment

Answer 18

Question 19

wilms tumor

incidence? affects what part of body?

2 types? timing differ? treatment outlook?

Answer 19

Question 20

Wilms pathogen and genetics

risk of wilms increased with?

1. first group has what syndrome? characterized by? incidence of wilms? chromo problem?

1st/2nd hit?

Answer 20

Question 21

wilms in congenital malformations

2. what syndrome? this group has very high chance of wilms tumor.

disease characterized by? gene abnormal?

this gene and renal/gonads

Answer 21

Question 22

wilms congenital malformations

3. distinct from other two. what syndrome? characterized by? what mechanism is happening? where? (what gene/location)

what gene/protein is activated? it is usually? other way it can be expressed?

Answer 22

Question 23

wilms tumors

what is also important in wilms tumor? part of what pathway? works together with?

what is a nephrogenic rest? similar how? differ?

increased risk for?

Answer 23

Question 24

Wilms tumor morph

morphology? location?

micro-characterized by? 3 cell types?

stromal cells?

anaplasia? this correlates with?

Answer 24

Question 25

wilms tumor clin features

present with?

outlook?

adverse prognosis?

increased risk of?

causes of these risks?

Answer 25