Neoplasia 3 Molecular Basis: Other Factors Leading to Cancer Flashcards
type of metabolism that cancer cells tend to use despite what conditions? this is called what?
used to visualize tumors?
is it cancer specific?
why undergo this type of metabolism and not normal way?
is there still oxidative phosphorylation?
how is warburg effect triggered in growing cells?
important points of crosstalk between what two things? examples 3
- p- effect?
- RTK- this causes what to happen? important enzymes? 2
- M- this does what?
tumor suppressors often inhibit what?
Autophagy- in what conditions would this occur?
friend? foe?
Evasion of apoptosis
how is thsi a problem?
anoikis?
bio pathways that lead to programmed cell death
death receptor? apoptosis pathway most frequently disabled in cancer?
intrinsic pathway- stimuli? leads to release of? pro-apoptotic proteins? anti? third set of proteins? BAD and BAX will do what? this will bind to? caspase? caspases held in check via?
Extrinsic pathway- stim by? this leads to? protein? recruits? caspase? cross talk?
best established ways cancer disrupts apoptosis? specific cancer? chromosome? leads to cancer how?
this type and treatment?
other protein/gene involved with avoiding apoptosis? normal proteins that it uses?
extrinsic pathway and cancer- 2 ways?
evasion of apoptosis
Key Concepts- apop thorugh what pathways?
more common pathway disruption in cancer?
what gene fucked up in B-cell lymphomas?
in drug resistance?
cancer cells and immortality?
3 factors critical to immortality?
immortal
evasion of senescence- what would normally cause it?
Immortal
Evasion of mitotic crisis
what is mitotic crisis? normally what kills?
if mutated what happens? end result?
if in crisis what will help? 2 ways?
immortal
self renewal- comes from being what type of cell?
what allows self-renewal? name of the two types?
immortal
since cancers are immortal must contain what cells?
cancer stem cells from transformation of stem cells or conversion of somatic? ex?
treatments concerning cancer stem cells?
Angiogenesis:
without cant enlarge past?
neovascularization dual effect on tumor growth?
normal vessels made?
important for what process?
normal angiogenesis controlled by? so in cancer?
inhibitors?
local balance of angiogenic and anti factors influenced by what factors? 3
- lack of oxygen leads to? activates transcription of? these do what?
- mutations involving tumor suppressors?
- transcription of via what signaling?
Angiogenesis and treatment?
Key concepts
hypoxia leads to?
other factors regulate angio?
treatment outcome?
invasion and metastasis
result of what? major cause of? metastasis inefficient how?
2 phases of metastatic cascade?