Neoplasia 5 Lab Diagnosis Flashcards
histologic and cytologic methods
lab diagnosis hard? what is?
sampling approaches of lab specimen?
frozen good?
Fine-needle aspiration
what is it? used on what type of lesions?
compared to needle biopsies?
cytologic smears
often used for? or what other situations?
limits of histo?
what overcomes limitations?
immunohistochemistry
what is it? helpful in what 3 situations?
flow cytometry
used for?
circulating tumor cells detected by?
Molecular and cytogenetic diagnostics
diagnosis of malignant neoplasms
how?
DNA microarrays for?
prognosis of malignant neoplasms
how so?
detection of minimal residual disease? monitors what? via?
diagnosis of hereditary predisposition to cancer
how so?
Guiding therapy with oncoprotein directed drugs
important why?
future of diagnosis
large scale anylsis. most common method?
DNA?
cost?
future
circos plots say what?
impact of cancer genome sequencing to date where?
helpful for what?
future
targeted therapies iportant?
best way to assess tumor: cell interactions
Tumor markers
biochem assays and tumor associated enzymes can be sued for?
PSA?
what problems with PSA?
tumor markers
other markers used? 4
CEA for?
AFP?
HCG?
CA-125
cell free DNAs evaluated as markers?