Path Key Points 4 Flashcards
Sleeping sickness
Trypanosoma brucei
Subcutaneous chancre at bite site
Fever, weakness, arthralgia, headache
Chagas disease
Trypansoma cruzi
Red nodule at bite site
Acute - swollen eyelids, fever, diarrhoea, vomiting, lethargy
Chronic - colon/cardiac/oesophageal dilation
Wilson’s disease
Cirrhosis, parkinsonism, seizures, dementia
Pemphigoid
Autimmune deep bullous
Nikolsky sign -ve
Pemphigus
Autoimmune bullous disease
Nikolsky sign +ve
Psoriasis
Salmon-pink plaque + silver white scale on extensor surfaces
Pityriasis rosea
Single scaly salmon-pink macule <5cm
Becomes a fir tree pattern after a few days
Lichen planus
Pruritic, purple, polygonal, planar, papular, plaques, pearl sheen
Acute tubular necrosis
Damage to tubular epithelium –> AKI
Ischaemic/toxic injury - loss of polarity, glomerular back pressure, interstitial leakage
IgA nephropathy
Few days after infection
Post-streptococcal glomerulonephritis
Few weeks after infection
Osteochondroma
10-30 years
Bone cancer of large joints
Osteoid osteoma
Dull pain
Bone cancer
X-ray - central nidus and sclerotic rim
Endochondroma
10-40 years
Bone cancer of small joints
Pyoderma gangrenosum
Necrotic ulcer with purple edges
Caused by UC, CD, RA, AML, CML, PRV, multiple myeloma