Path Key Points 4 Flashcards

1
Q

Sleeping sickness

A

Trypanosoma brucei
Subcutaneous chancre at bite site
Fever, weakness, arthralgia, headache

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2
Q

Chagas disease

A

Trypansoma cruzi
Red nodule at bite site
Acute - swollen eyelids, fever, diarrhoea, vomiting, lethargy
Chronic - colon/cardiac/oesophageal dilation

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3
Q

Wilson’s disease

A

Cirrhosis, parkinsonism, seizures, dementia

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4
Q

Pemphigoid

A

Autimmune deep bullous

Nikolsky sign -ve

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5
Q

Pemphigus

A

Autoimmune bullous disease

Nikolsky sign +ve

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6
Q

Psoriasis

A

Salmon-pink plaque + silver white scale on extensor surfaces

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7
Q

Pityriasis rosea

A

Single scaly salmon-pink macule <5cm

Becomes a fir tree pattern after a few days

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8
Q

Lichen planus

A

Pruritic, purple, polygonal, planar, papular, plaques, pearl sheen

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9
Q

Acute tubular necrosis

A

Damage to tubular epithelium –> AKI

Ischaemic/toxic injury - loss of polarity, glomerular back pressure, interstitial leakage

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10
Q

IgA nephropathy

A

Few days after infection

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11
Q

Post-streptococcal glomerulonephritis

A

Few weeks after infection

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12
Q

Osteochondroma

A

10-30 years

Bone cancer of large joints

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13
Q

Osteoid osteoma

A

Dull pain
Bone cancer
X-ray - central nidus and sclerotic rim

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14
Q

Endochondroma

A

10-40 years

Bone cancer of small joints

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15
Q

Pyoderma gangrenosum

A

Necrotic ulcer with purple edges

Caused by UC, CD, RA, AML, CML, PRV, multiple myeloma

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16
Q

Polymyositis

A

Weakness, pain and swelling of proximal muscles and facial muscles, ptosis, dysphagia

17
Q

Dermatitis herpetiformis

A

Symmetrical, itchy papulovesicular rash on extensor surfaces (elbows, buttocks)
Associated with gluten intake in Coeliac’s disease

18
Q

Dengue fever

A

Abrupt onset fever, retrobulbar pain, facial flushing

Generalised maculopapular rash

19
Q

Guttate psoriasis

A

Abrupt onset small salmon-pink lesions in young adults/children
Strep throat infection 2/3 weeks before

20
Q

Giardia

A

Bloating, flatulence
From India
Mx - Metronidazole PO 400mg tds for 5 days