Path 1.2 Necrosis

Question 1

types of necrosis

Answer 1

coagulative, 
liquifactive, 
caseous, 
fat, 
fibrinoid, 
gangrenous

Question 2

coagulative

Answer 2

preservation of cell outlines of dead cells,

intense staining with eosin, more eosin binding sites bc the cell is dying

Question 3

liquifactive necrosis

Answer 3

tissue turns to liquid

Question 4

liquifactive necrosis etiology

Answer 4

occurs in absess (liquid-pus–a collection of neutrophils),
also occurs in the CNS (bc the brain when its injured does everything it can to maintain its 3D structure - surrounding brain tissue froms a gliosis to try and keep the 3D structure in the brain - by forming scars

Question 5

caseous necrosis

Answer 5

cheese-like (cream cheese)

Question 6

caseous necrosis etiology

Answer 6

majority is due to granulomas inflammation and TB.
Some fungi can also form this, this is the macrophages forming this by releasing cytokines that kill the tissue in the particular area

Question 7

fat necrosis

Answer 7

chalky white lesion - you get soaponification of fat liberating the fatty acid that react with calcium to form calcium salts in fatty acid.
Drop in calcium concentration is something you would see in fat necrosis

Question 8

fat necrosis example

Answer 8

injury to pancreas and it releases enzymes like lipases,

the lipases react with the fatty deposits in the omentum

Question 9

ex 2 of fat necrosis

Answer 9

fatty area of the body subjected to trauma

–>whole area of fat dies and just goes away

Question 10

Fibrinoid necrosis

Answer 10

walls of organs, bc of damage to the vessles. Caused by malignant hypertension and vasculitis due to increased permeability of vessel walls