Parvoviridae mycv Flashcards
Smallest of the DNA viruses (~22nm)
* Small, non-enveloped icosahedral capsid
* Linear single stranded DNA genome
* 2 subfamilies
1
2
Parvoviridae
- Densovirinae
Parvovirinae
infects invertebrates (insects and crustaceans)
Densovirinae
infects vertebrates
- 3 important genus affecting humans __,__,__
Parvovirinae
- (Dependoparvovirus, Erythroparvovirus, Bocaparvovirus)
-Faudovirus (Canine Parvovirus), Protoparvovirus (FelineParvovirus), Tetraparvovirus (Porcine parvovirus)
- Characterized by their dependance on helper viruses such as __ or ___ for replication
- Adeno-associated viruses (AAV)
- Can cause mild respiratory illness
- Can be used in gene-replacement therapy because of its low immunogenicity and wide tissue tropism
Dependoparvovirus
- adenoviruses or herpesviruses
- Associated with a variety of respiratory infections including bronchiolitis, pneumonia, and upper respiratory tract infections which may become severe in young children
- MOT: ___
- Diagnosis:___,___,__,__,__
Bocaparvovirus (Human Bocavirus (HBoV))
- respiratory droplets
- PCR, Antigen detection, Immunofluorescence, Electron microscopy
Cell receptor: ___ found in the surface of red blood cells, erythroid progenitors, vascular endothelium and fetal myocytes
* Infections causes no symptom or mild illness such as flu symptoms, rashes and joint pains.
* slapped cheek” rash in children, and joint pains in adults
* Individual with weakened immune system it can cause low blood count
* Infection during pregnancy can lead to miscarriage
Erythroparvovirus (Parvovirus B19)
- P antigen
Epidemiology
* Virus spreads by respiratory and oral secretions
* Worldwide prevalence typically in children
* Incubation period: ___
* At risk groups: Pregnant women, immunocompromised patients and
those with hemolytic anemia
Parvovirus B19
- 12-18 days
Parvovirus B19 Clinical Diseases
- Mild respiratory tract illness
- Polyarthropathy Syndrome
- Aplastic crisis
- Erythema infectiosum (fifth disease)
- Hydrops Fetalis
swelling of joints. Usually lasts 1-3 weeks but can last for months. Goes away without any long-term
problems
Polyarthropathy Syndrome
due to infection of red blood cell pre-cursors and
immune-mediated destruction
Aplastic crisis
”slapped-cheek disease”
* Common in children aged 4-11 years
* May be associated with lymphadenopathy and joint symptoms
Erythema infectiosum (fifth disease)
excessive fluid build up in the fetus
Hydrops Fetalis
MOT: Respiratory droplets
Diagnosis:
___,__,___
Treatment: supportive care
Parvovirus B19
* Antibody Testing (Parvovirus IgM)-
acute infection
* PCR-acute infection in
immunocompromised and patients
with aplastic crisis
* PCR and Antibody testing using
cord blood-diagnosis of fetal
infection
22nm
no envelope
icosahedral
single stranded
parvovirus b19 virus
human bocavirus
humanbufavirus
parv4
55nm
no envelope
icosahedral
double stranded circular
papillomaviridae
- human papillomaviruses
