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MIDTERMS > ADENOVIRIDAE > Flashcards

ADENOVIRIDAE Flashcards

1
Q

Naked icosahedral capsid, linear double stranded DNA
• ~____ size
• First isolated from cultures of human ___ and __ in the __
• Stable and viable for about ___ at___ but inactivated at ___.

A

Adenoviridae
- 70-90nm
- adenoids and tonsils
-1950
- a week at 37°C
- 50°C

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2
Q

Adenoviridae Resistant to ___ and __
• Tropism: ___

A
  • ether and bile salts
  • nucleus of epithelial cells
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3
Q

Adenoviridae Genus:
1
2

A
  • Mastadenovirus-causes human infection
  • Aviadenovirus-infects birds
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4
Q

__ of human adenovirus divided into ____
• Commonly causes ___ and ___ but is also associated with __, ___,___ for
immunocompromised patients
• MOT: __, __,___

A
  • 85 serotypes
  • seven species (A through G)
  • respiratory and gastrointestinal disease
  • conjunctivitis, keratitis and disseminated multi-organ disease
  • respiratory droplets, fecal-oral route,
    fomites
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5
Q

__ of human adenovirus divided into ____
• Commonly causes ___ and ___ but is also associated with __, ___,___ for
immunocompromised patients
• MOT: __, __,___

A
  • 85 serotypes
  • seven species (A through G)
  • respiratory and gastrointestinal disease
  • conjunctivitis, keratitis and disseminated multi-organ disease
  • respiratory droplets, fecal-oral route,
    fomites
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6
Q

Adenoviridae Incubation period:
___- Respiratory infection
___ - gastroenteritis

A

2-14 days
3-10 days

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7
Q

Adenovirus Group A

A

Serotype 12, 18, 21

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8
Q

Adenovirus Group B

A

Serotype 3,7,11,14, 16,21,34,35

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9
Q

Adenovirus Group C

A

Serotype 1, 2, 5, 6

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10
Q

Adenovirus Group D

A

Serotype 8-10, 13, 15, 17, 19,20, 22-30, 32, 33, 36-39, 42-47

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11
Q

Adenovirus Group D

A

Serotype 8-10, 13, 15, 17, 19,20, 22-30, 32, 33, 36-39, 42-47

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12
Q

Adenovirus Group E

A

Serotype 4

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13
Q

Adenovirus Group E

A

Serotype 4

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14
Q

Adenovirus Group F

A

Serotype 40, 41

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15
Q

Acute febrile Pharyngitis
Epidemic
Endemic

A

Infants young children 3,4,7
Infants young children 1,2,5,6

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16
Q

Pneumonia

A

Infants
1,2,3,7

17
Q

Acute Respiratory dse

A

Military recruits
4,7,14,21

18
Q

Pharyngoconjunctival fever

A

Older school age children
3,7

19
Q

Epidemic keratoconjunctivitis (ship yard eye)

A

Adults
8,19,37

20
Q

Follicular (swimming pool) conjunctivitis

A

Any age
3,4,11

21
Q

Diarrhea and vomiting

A

Infants, young children
40,41

22
Q

Intussusception

A

Infants
1,2,5

23
Q

Hemorrhagic cystitis

A

Infants, young children
11,21

24
Q

Disseminated infection

A

Immunocompromised e.g AIDS, renal, bone marrow and heart lung transplant recipients
5,11,34,35,43-47

25
Q

Respiratory Diseases

A

Pharyngitis
Pneumonia
Acute respiratory dse

26
Q

: the major cause of nonbacterial pharyngitis and tonsillitis, presenting as febrile common cold.
• Types ___ are commonly responsible

A

Pharyngitis
- 1-7

27
Q

___ and ___ are associated in adults resembling primary ____
• particularly types __,___, and __ are thought to be responsible for about
10–20% in childhood.
• In infants and young children type ___ may lead to more serious and even fatal.

A
  • Adenovirus types 3 and 7
  • atypical pneumonia
  • 3, 7, and 21
    -7
28
Q

the cause among military recruits.
• Serotypes __, ___ and __ are the agents commonly isolated

A

Acute respiratory dse
- 4, 7 and 21

29
Q

Eye infections

A

Pharyngoconjunctival fever
Epidemic keratoconjunctivitis (EKC)
Acute follicular conjunctivitis

30
Q

: tends to occur in outbreaks, such
as at children’s summer camps (swimming pool conjunctivitis),
and is associated with serotypes __,___,__

A

Pharyngoconjunctival fever
- 3, 7 and 14

31
Q

a serious condition which may appear as an epidemics, usually caused by type __ and less often by types __ and __.
• Occurs mainly in adults and is highly contagious

A

Epidemic keratoconjunctivitis EKC
- 8
- 19 and 37

32
Q

: Types __ __ and ___ are commonly
responsible.
• Adenoviral and chlamydial conjunctivitis are clinically similar.

A

Acute follicular conjunctivitis
- 3,4,11

33
Q

Gastrointestinal Disease
: Some fastidious adenoviruses can cause this in children serotypes __ and __

A

Diarrhea
40 and 41

34
Q

Systemic Infection Adenovirus
1
2

A

1 Meningitis (serotype 3 and 7)
2 Adenovirus infection in immunocompromised patients
➢ SCID-pneumonia and hepatitis
➢ AIDS-latent kidney infections (urine), subgenus D seen in stool
➢ Bone marrow transplant recipients

35
Q

Treatment and Prevention of Adenovirus
• No specific antiviral chemotherapy (supportive care only)
• For swimming pool-associated conjunctivitis- ___
• Vaccine: ___

A
  • adequate levels of chlorine in water
  • Non-attenuated live Adenovirus types 4, 7, and 21 packaged in enteric capsules (military only)
36
Q

• Members of Parvoviridae
• Dependent with __ or ___ to provide
missing functions

A

AAVs (Adenovirus Associated Viruses)
- Adenoviruses or Herpes Simplex Virus

MIDTERMS (19 decks)

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