ADENOVIRIDAE Flashcards
Naked icosahedral capsid, linear double stranded DNA
• ~____ size
• First isolated from cultures of human ___ and __ in the __
• Stable and viable for about ___ at___ but inactivated at ___.
Adenoviridae
- 70-90nm
- adenoids and tonsils
-1950
- a week at 37°C
- 50°C
Adenoviridae Resistant to ___ and __
• Tropism: ___
- ether and bile salts
- nucleus of epithelial cells
Adenoviridae Genus:
1
2
- Mastadenovirus-causes human infection
- Aviadenovirus-infects birds
__ of human adenovirus divided into ____
• Commonly causes ___ and ___ but is also associated with __, ___,___ for
immunocompromised patients
• MOT: __, __,___
- 85 serotypes
- seven species (A through G)
- respiratory and gastrointestinal disease
- conjunctivitis, keratitis and disseminated multi-organ disease
- respiratory droplets, fecal-oral route,
fomites
__ of human adenovirus divided into ____
• Commonly causes ___ and ___ but is also associated with __, ___,___ for
immunocompromised patients
• MOT: __, __,___
- 85 serotypes
- seven species (A through G)
- respiratory and gastrointestinal disease
- conjunctivitis, keratitis and disseminated multi-organ disease
- respiratory droplets, fecal-oral route,
fomites
Adenoviridae Incubation period:
___- Respiratory infection
___ - gastroenteritis
2-14 days
3-10 days
Adenovirus Group A
Serotype 12, 18, 21
Adenovirus Group B
Serotype 3,7,11,14, 16,21,34,35
Adenovirus Group C
Serotype 1, 2, 5, 6
Adenovirus Group D
Serotype 8-10, 13, 15, 17, 19,20, 22-30, 32, 33, 36-39, 42-47
Adenovirus Group D
Serotype 8-10, 13, 15, 17, 19,20, 22-30, 32, 33, 36-39, 42-47
Adenovirus Group E
Serotype 4
Adenovirus Group E
Serotype 4
Adenovirus Group F
Serotype 40, 41
Acute febrile Pharyngitis
Epidemic
Endemic
Infants young children 3,4,7
Infants young children 1,2,5,6
Pneumonia
Infants
1,2,3,7
Acute Respiratory dse
Military recruits
4,7,14,21
Pharyngoconjunctival fever
Older school age children
3,7
Epidemic keratoconjunctivitis (ship yard eye)
Adults
8,19,37
Follicular (swimming pool) conjunctivitis
Any age
3,4,11
Diarrhea and vomiting
Infants, young children
40,41
Intussusception
Infants
1,2,5
Hemorrhagic cystitis
Infants, young children
11,21
Disseminated infection
Immunocompromised e.g AIDS, renal, bone marrow and heart lung transplant recipients
5,11,34,35,43-47
Respiratory Diseases
Pharyngitis
Pneumonia
Acute respiratory dse
: the major cause of nonbacterial pharyngitis and tonsillitis, presenting as febrile common cold.
• Types ___ are commonly responsible
Pharyngitis
- 1-7
___ and ___ are associated in adults resembling primary ____
• particularly types __,___, and __ are thought to be responsible for about
10–20% in childhood.
• In infants and young children type ___ may lead to more serious and even fatal.
- Adenovirus types 3 and 7
- atypical pneumonia
- 3, 7, and 21
-7
the cause among military recruits.
• Serotypes __, ___ and __ are the agents commonly isolated
Acute respiratory dse
- 4, 7 and 21
Eye infections
Pharyngoconjunctival fever
Epidemic keratoconjunctivitis (EKC)
Acute follicular conjunctivitis
: tends to occur in outbreaks, such
as at children’s summer camps (swimming pool conjunctivitis),
and is associated with serotypes __,___,__
Pharyngoconjunctival fever
- 3, 7 and 14
a serious condition which may appear as an epidemics, usually caused by type __ and less often by types __ and __.
• Occurs mainly in adults and is highly contagious
Epidemic keratoconjunctivitis EKC
- 8
- 19 and 37
: Types __ __ and ___ are commonly
responsible.
• Adenoviral and chlamydial conjunctivitis are clinically similar.
Acute follicular conjunctivitis
- 3,4,11
Gastrointestinal Disease
: Some fastidious adenoviruses can cause this in children serotypes __ and __
Diarrhea
40 and 41
Systemic Infection Adenovirus
1
2
1 Meningitis (serotype 3 and 7)
2 Adenovirus infection in immunocompromised patients
➢ SCID-pneumonia and hepatitis
➢ AIDS-latent kidney infections (urine), subgenus D seen in stool
➢ Bone marrow transplant recipients
Treatment and Prevention of Adenovirus
• No specific antiviral chemotherapy (supportive care only)
• For swimming pool-associated conjunctivitis- ___
• Vaccine: ___
- adequate levels of chlorine in water
- Non-attenuated live Adenovirus types 4, 7, and 21 packaged in enteric capsules (military only)
• Members of Parvoviridae
• Dependent with __ or ___ to provide
missing functions
AAVs (Adenovirus Associated Viruses)
- Adenoviruses or Herpes Simplex Virus
