Parvoviridae Flashcards
T/F: Parvoviridae is very stable,, making disinfection of contaminated premises very difficult
True
T/F: Infection of Parvoviridae leads to large intranuclear inclusion bodies
True
T/F: human parvovirus B19 is the same found in dogs and can be transmitted to humans from dogs or cats
False, B19 is different from that seen in dogs and cats and there is no evidence of transmission
What disease does feline parvovirus cause?
Feline panleukopenia (FPV)
T/F: FPV is not highly contagious or fatal
False, it is highly contagious and often fatal in cats and sever in kittens
How is FPV maintained in a population?
By environmental persistence
What are 3 ways FPV can be transmitted?
- Oro-nasally by infected animals, feces, secretions, or contaminated fomites
- In-utero
- Mechanical
What is the hallmark of he disease FPV?
Panleukopenia = destruction of WBC elements
In-utero infection of FPV of pregnant queens leads to what?
- Early fetal death
- Abortion
- Mummified births
In-utero infection of FPV closer to end of gestation leads to what?
- Kittens born with varying degrees of neural damage
T/F: cerebellar damage form FPV has been commonly reported
True
CS of FPV is most commonly seen in what age group of kittens?
3-5 months
MLV should not be administer to what 4 animals?
- Pregnant cats
- Immunosuppressed cats
- Sick cats
- Kittens less than 4 weeks old
What is one of the most common infectious disease in dogs?
Canine parvovirus 2 (CPV2)
What are the three antigenic variants of CPV2?
CPV2a, CPB2b, CPV2c
Which who antigenic variants of CPV2 are seen in N. America?
CPV2b and CPV2c
Similar to FPV, CPV2 has what 3 main CS?
- Enteritis
- Myocarditis
- Panleukopenia
Enteritis caused by CPV2 leads to what primary CS?
Hemorrhagic diarrhea
T/F: serology is the best method to test CPV
False, not the best method bc most dogs have been vaccinated or previously exposed to CPV
Due to potential damage by CPV to myocardial or cerebellar cells, which vaccine is preferred in pregnant dogs or colostrum-deprived puppies 6-8 weeks of age?
Inactivated vaccines
T/F: oseltamivir can be used in the Tx of canine parvoviral enteritis
True
T/F: Porcine parvovirus is an infectious cause of repro failure in swine
True
What is the acronym for some of the manifestations of Porcine parvovirus?
SMEDI (stillbirth, mummification, embryonic death, infertility)
What is the transmission route of porcine parvovirus (PPV)?
Oronasally in non-immune pregnant sows followed by transplacental transmission (venereal transmission is possible)
T/F: death at different stages of pregnancy is typical of PPV infections
True
What is a hallmark sign of PPV?
The increase of mummified fetuses after a normal gestation period
T/F: abortions are common in PPV infections
False, abortions are uncommon
T/F: PPV infections of embryo/fetus (<30days) leads to death and resorption of embryo/fetus, and the dam may return to estrus
True
What happens during PPV infection of an early fetus (30-70days)?
Fetuses die and become mummified
What happens during PPV infection of late fetus (>70days to term)?
Frequently develop lesions, but also mount an immune response and usually survive in-utero
T/F: boars, sows, and gilts usually have inapparent CS or subclinical infections
True
T/F: The major cause of SMEDI is porcine parvovirus
True
T/F: serologic tests are of good value to Dx PPV
False; they are of limited value bc virus is widespread and vaccination may interfere
T/F: PPV can cause persistent infections with periodical shedding of virus
True
What is the best way to vaccinate for PPV?
Vaccinate all susceptible breeding stock twice, 2 weeks apart, several weeks before breeding
