Circoviridae Flashcards
What two infections does Circovirus cause?
- Porcine circovirus type-1 (non-path)
2. Porcine circovirus type-2 (PMWS)
What infection does gyrovirus cause?
Chicken infectious anemia
T/F: circovirus and gyrovirus both have circular, single stranded DNA, but circrovirus has ambisense DNA and gyrovirus has negative sense DNA
True
T/F: For circoviridae, virus replication occurs in non active cell
False, occurs in actively dividing cell
What cell structure does DNA replication occur for circoviridae?
Nucleus
Who is most commonly affects by PMWS caused by porcine circovirus 2 (PCV2)?
Pigs at 4-6 or 2-3 weeks post-weaning
What is the most common method of spread for PMWS caused by PCV2?
Fecal-oral transmission
T/F: Horizontal transmission occurs in swine with PMWS caused by PCV2
False, vertical transmission (transplacental infection)
How is PMWS caused by PCV2 distinctly characterized histologically?
Botryoid inclusion bodies in macrophages
Lymphoid depletion caused by PMWS causes a loss of what two types of cells?
B and T cells
T/F: subclinical infections are the most common CS of PMWS
True
T/F: PMWS can be severe with more pronounced lesions if there is a co-infection with other viruses
True
Is antigen detection for PMWS effective?
No, because most pigs are seropositive
What are 2 vaccinations for PMWS?
- Chimeric vaccine
2. Inactivated or baculoviruse-expressed vaccines
When are sows vaccinated for PMWS?
2 and 5 weeks antepartum