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RUSVM Virology Exam 2 > Adenoviridae > Flashcards

Adenoviridae Flashcards

1
Q

T/F: Adenoviruses are non-enveloped with a hexagonal outline

A

True

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2
Q

What is a very characteristic morphological feature of adenoviruses?

A

12 vertex penton capsomers each with a fiber protrude from capsid surface

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3
Q

Adenoviruses have intranuclear inclusion bodies that contain large numbers of what?

A

Virions

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4
Q

Since adenoviruses have penton fibers, what can they do to RBCs?

A

Agglutinate RBCs

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5
Q

T/F: most adenoviruses have wide host range

A

False, have narrow host ranges

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6
Q

What two diseases do many adenoviruses cause?

A
  1. Acute respiratory disease

2. Gastroenteric disease

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7
Q

Adenoviruses interfere wit the immune system, causing what?

A

Immunosuppression

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8
Q

T/F: Adenoviruses can establish long periods of latency

A

True.

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9
Q

T/F: under certain conditions, adenoviruses can be oncogenic

A

True

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10
Q

What are the two important genera of adenoviruses?

A
  1. Mastadenovirus (mammalian adenoviruses)

2. Aviadenovirus (avian adenoviruses)

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11
Q

T/F: In avian adenoviruses, each penton fiber is bifurcated and appears as two fibers

A

True

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12
Q

What causes infectious canine hepatitis (ICH)?

A

Canine adenovirus 1 (CAV1)

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13
Q

After an acute infection, CAV1 sheds in what for 6-9 months?

A

Sheds in urine for 6-9 months

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14
Q

What is the transmission route for CAV1?

A

Oronasal transmission

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15
Q

What is the source of infection for CAV1?

A

Secretions/excretions of infected dog
Contaminated fomites
Ectoparasites

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16
Q

What 4 organs are the main targets organs for CAV1?

A

Liver, kidneys, spleen, and lungs

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17
Q

T/F: The antibody titer of a dog is very crucial for infectious canine hepatitis caused by CAV1

A

True

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18
Q

T/F: in chronic cases with infectious canine hepatitis, cirrhosis can occur

A

True

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19
Q

T/F: In acute or chronic cases of infectious canine hepatitis, glomerulonephritis can occur

A

True

20
Q

What ocular lesion is seen in dogs during recovery or chronic cases of infections canine hepatitis?

A

Corneal edema (blue eye)

21
Q

T/F: An increase in CAV1 antibody production and formation of viral-antibody immune complexes contributes to the formation of corneal edema

A

True

22
Q

T/F: Compliment activation and neutrophil chemotaxis causes extensive damage to corneal epithelium, which will disrupt the intact corneal epithelium and allow aqueous humor to enter cornea

A

True

23
Q

T/F: Accumulation of edematous fluid w/in cornea stroma results inn corneal edema

A

True

24
Q

What are two complications of infectious canine hepatitis?

A
  1. Disseminated intravascular coagulation (DIC) resulting from damage to endothelium
  2. Bacterial pyelonephritis resulting from renal damage
25
Q

Infectious canine hepatitis CS are observed in dogs of what age group?

A

Less than 1 year of age

26
Q

Which leads to death quicker: peracute or acute cases of ICH?

A

Peracute

27
Q

What are some general CS of acute ICH?

A

Depression, anorexia, vomiting, fever, abdominal pain/tenderness, hepatomegaly, jaundice, swollen lymph nodes, subQ edema

28
Q

T/F: Icterus is common in early acute phase of ICH

A

False, it is uncommon

29
Q

T/F: corneal edema and anterior uveitis occur when clinical signs of ICH begins

A

True

30
Q

T/F: During necropsy and histopathology, paint-brush hemorrhages, centrilobular liver necrosis, and grey/white foci on kidney can be seen

A

True

31
Q

What two Dx methods are important in ICH?

A

Biochemistry and hematology

32
Q

Virus isolation for ICH is mainly done with what body fluid?

A

Urine

33
Q

What is the vaccine of choice for ICH?

A

CAV2 attenuated live virus strain

34
Q

T/F: Maternal Ab’s do not interfere with active immunization of puppies

A

False, they do interfere with puppies until they are 9-12 weeks of age

35
Q

Canine infectious tracheobronchitis (CITB) is commonly referred to as what?

A

Kennel cough

36
Q

What is the main cause of kennel cough (CITB)?

A

Canine adenovirus 2 (CAV2)

37
Q

With ITB is life threatening: uncomplicated or complicated ITB?

A

Complicated ITB

38
Q

What is the Tx plan for kennel cough?

A

Antitussives in combo with bronchodilators

39
Q

What are two types of equine adenoviruses?

A

Equine adenoviruse 1 and 2 (EAV1 and EAV2)

40
Q

Which equine adenovirus is associated with SCID in foals?

A

EAV1

41
Q

What are the CS in SCID foals?

A

Severe bronchiolitis and pneumonia

Respiratory distress

42
Q

What disease does avian adenovirus cause in chickens?

A

Inclusion body hepatitis egg drop syndrome ‘76

43
Q

What disease does avian adenovirus cause in ducks?

A

Hepatitis (rare)

44
Q

What disease does avian adenovirus cause in quail?

A

Bronchitis

45
Q

What disease does avian adenovirus cause in turkeys?

A

Hemorrhagic enteritis egg drop syndrome

46
Q

What disease does avian adenovirus cause in pheasants?

A

Marble spleen disease

RUSVM Virology Exam 2 (10 decks)

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