Adenoviridae Flashcards
T/F: Adenoviruses are non-enveloped with a hexagonal outline
True
What is a very characteristic morphological feature of adenoviruses?
12 vertex penton capsomers each with a fiber protrude from capsid surface
Adenoviruses have intranuclear inclusion bodies that contain large numbers of what?
Virions
Since adenoviruses have penton fibers, what can they do to RBCs?
Agglutinate RBCs
T/F: most adenoviruses have wide host range
False, have narrow host ranges
What two diseases do many adenoviruses cause?
- Acute respiratory disease
2. Gastroenteric disease
Adenoviruses interfere wit the immune system, causing what?
Immunosuppression
T/F: Adenoviruses can establish long periods of latency
True.
T/F: under certain conditions, adenoviruses can be oncogenic
True
What are the two important genera of adenoviruses?
- Mastadenovirus (mammalian adenoviruses)
2. Aviadenovirus (avian adenoviruses)
T/F: In avian adenoviruses, each penton fiber is bifurcated and appears as two fibers
True
What causes infectious canine hepatitis (ICH)?
Canine adenovirus 1 (CAV1)
After an acute infection, CAV1 sheds in what for 6-9 months?
Sheds in urine for 6-9 months
What is the transmission route for CAV1?
Oronasal transmission
What is the source of infection for CAV1?
Secretions/excretions of infected dog
Contaminated fomites
Ectoparasites
What 4 organs are the main targets organs for CAV1?
Liver, kidneys, spleen, and lungs
T/F: The antibody titer of a dog is very crucial for infectious canine hepatitis caused by CAV1
True
T/F: in chronic cases with infectious canine hepatitis, cirrhosis can occur
True
T/F: In acute or chronic cases of infectious canine hepatitis, glomerulonephritis can occur
True
What ocular lesion is seen in dogs during recovery or chronic cases of infections canine hepatitis?
Corneal edema (blue eye)
T/F: An increase in CAV1 antibody production and formation of viral-antibody immune complexes contributes to the formation of corneal edema
True
T/F: Compliment activation and neutrophil chemotaxis causes extensive damage to corneal epithelium, which will disrupt the intact corneal epithelium and allow aqueous humor to enter cornea
True
T/F: Accumulation of edematous fluid w/in cornea stroma results inn corneal edema
True
What are two complications of infectious canine hepatitis?
- Disseminated intravascular coagulation (DIC) resulting from damage to endothelium
- Bacterial pyelonephritis resulting from renal damage
Infectious canine hepatitis CS are observed in dogs of what age group?
Less than 1 year of age
Which leads to death quicker: peracute or acute cases of ICH?
Peracute
What are some general CS of acute ICH?
Depression, anorexia, vomiting, fever, abdominal pain/tenderness, hepatomegaly, jaundice, swollen lymph nodes, subQ edema
T/F: Icterus is common in early acute phase of ICH
False, it is uncommon
T/F: corneal edema and anterior uveitis occur when clinical signs of ICH begins
True
T/F: During necropsy and histopathology, paint-brush hemorrhages, centrilobular liver necrosis, and grey/white foci on kidney can be seen
True
What two Dx methods are important in ICH?
Biochemistry and hematology
Virus isolation for ICH is mainly done with what body fluid?
Urine
What is the vaccine of choice for ICH?
CAV2 attenuated live virus strain
T/F: Maternal Ab’s do not interfere with active immunization of puppies
False, they do interfere with puppies until they are 9-12 weeks of age
Canine infectious tracheobronchitis (CITB) is commonly referred to as what?
Kennel cough
What is the main cause of kennel cough (CITB)?
Canine adenovirus 2 (CAV2)
With ITB is life threatening: uncomplicated or complicated ITB?
Complicated ITB
What is the Tx plan for kennel cough?
Antitussives in combo with bronchodilators
What are two types of equine adenoviruses?
Equine adenoviruse 1 and 2 (EAV1 and EAV2)
Which equine adenovirus is associated with SCID in foals?
EAV1
What are the CS in SCID foals?
Severe bronchiolitis and pneumonia
Respiratory distress
What disease does avian adenovirus cause in chickens?
Inclusion body hepatitis egg drop syndrome ‘76
What disease does avian adenovirus cause in ducks?
Hepatitis (rare)
What disease does avian adenovirus cause in quail?
Bronchitis
What disease does avian adenovirus cause in turkeys?
Hemorrhagic enteritis egg drop syndrome
What disease does avian adenovirus cause in pheasants?
Marble spleen disease
