Papillomaviridae Flashcards
T/F: Papillomaviridae can transform cultured cells
True
What do papillomaviruses produce?
Papillomas (warts) on skin and mucous membranes
T/F: Papillomaviruses are usually species and site specific
True
Replication of papillomaviruses is linked intimately to growth and differentiation of cells in what epithelium?
Stratified squamous epithelium of skin and some mucous membranes
T/F: In benign warts, the papillomavirus DNA is integrated into the host cell DNA
False; DNA is episomal, meaning it is NOT integrated into host cell DNA and persists as an autosomal replicating episome
T/F: in papillomavirus-induced malignant cancers, the viral DNA is integrated into the host
True
What is the most common host for papillomaviruses?
Cattle; bovine papillomatosis
What are two transmission methods of papillomaviruses?
- Contaminated fomites
2. Sexual transmission of venereal warts in cattle
What causes a fibropapilloma?
Bovine papillomavirus types 1, 2, and 5
What are the common locations of fibropapillomas?
Common on udder, teats, head, neck and shoulders
Also on omasum, vagina, vulva, penis and anus
What causes cutaneous papillomas?
Bovine papillomaviruses type 3
What causes transient papillomas in the alimentary tract?
Bovine papillomavirus type 4
T/F: ingestion of bracken fern can result in transition to invasive carcinoma of alimentary tract
True.
Which papillomavirus types contribute to “enzootic hematuria” syndrome after cattle ingest bracken fern
Type 1 and 2
How would bovine papillomatosis be Tx?
- Surgical excision or cryosurgery w/liquid nitrogen
- Topical agents
- Bovine interferon-alpha
T/F: the wart vaccine for bovine papillomatosis is a killed vaccine
True
What is the usually location of canine oral papillomatosis?
Usually on lips, spread to buccal mucosa, tongue, palate, and pharynx
Can see ocular warts too
T/F: dogs that recovered from canine oral papillomatosis are resistant to reinfection
True
What are the most common neoplasms in horses?
Equine sarcoids
Which bovine papillomaviruse types are associated with equine sarcoids?
Types 1 or 2
T/F: sarcoids can metastasize
False, they are locally invasive benign fibroblastic skin tumors
Where do equine sarcoids lesions commonly occur?
In traumatized areas
What are the Tx for equine sarcoids?
Cryotherapy
Surgical or laser excision
Local immune modulation
Local radiotherapy
