Papillomaviridae

Question 1

T/F: Papillomaviridae can transform cultured cells

Answer 1

True

Question 2

What do papillomaviruses produce?

Answer 2

Papillomas (warts) on skin and mucous membranes

Question 3

T/F: Papillomaviruses are usually species and site specific

Answer 3

True

Question 4

Replication of papillomaviruses is linked intimately to growth and differentiation of cells in what epithelium?

Answer 4

Stratified squamous epithelium of skin and some mucous membranes

Question 5

T/F: In benign warts, the papillomavirus DNA is integrated into the host cell DNA

Answer 5

False; DNA is episomal, meaning it is NOT integrated into host cell DNA and persists as an autosomal replicating episome

Question 6

T/F: in papillomavirus-induced malignant cancers, the viral DNA is integrated into the host

Answer 6

True

Question 7

What is the most common host for papillomaviruses?

Answer 7

Cattle; bovine papillomatosis

Question 8

What are two transmission methods of papillomaviruses?

Answer 8

1. Contaminated fomites

2. Sexual transmission of venereal warts in cattle

Question 9

What causes a fibropapilloma?

Answer 9

Bovine papillomavirus types 1, 2, and 5

Question 10

What are the common locations of fibropapillomas?

Answer 10

Common on udder, teats, head, neck and shoulders

Also on omasum, vagina, vulva, penis and anus

Question 11

What causes cutaneous papillomas?

Answer 11

Bovine papillomaviruses type 3

Question 12

What causes transient papillomas in the alimentary tract?

Answer 12

Bovine papillomavirus type 4

Question 13

T/F: ingestion of bracken fern can result in transition to invasive carcinoma of alimentary tract

Answer 13

True.

Question 14

Which papillomavirus types contribute to “enzootic hematuria” syndrome after cattle ingest bracken fern

Answer 14

Type 1 and 2

Question 15

How would bovine papillomatosis be Tx?

Answer 15

1. Surgical excision or cryosurgery w/liquid nitrogen
2. Topical agents
3. Bovine interferon-alpha

Question 16

T/F: the wart vaccine for bovine papillomatosis is a killed vaccine

Answer 16

True

Question 17

What is the usually location of canine oral papillomatosis?

Answer 17

Usually on lips, spread to buccal mucosa, tongue, palate, and pharynx

Can see ocular warts too

Question 18

T/F: dogs that recovered from canine oral papillomatosis are resistant to reinfection

Answer 18

True

Question 19

What are the most common neoplasms in horses?

Answer 19

Equine sarcoids

Question 20

Which bovine papillomaviruse types are associated with equine sarcoids?

Answer 20

Types 1 or 2

Question 21

T/F: sarcoids can metastasize

Answer 21

False, they are locally invasive benign fibroblastic skin tumors

Question 22

Where do equine sarcoids lesions commonly occur?

Answer 22

In traumatized areas

Question 23

What are the Tx for equine sarcoids?

Answer 23

Cryotherapy
Surgical or laser excision
Local immune modulation
Local radiotherapy