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RUSVM Virology Exam 2 > Herpesviridae part 2 > Flashcards

Herpesviridae part 2 Flashcards

1
Q

What does canine herpesvirus-1 (CHHV-1). Cause in puppies?

A

Hemorrhagic disease of puppies (fading puppy syndrome)

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2
Q

What are the 3 primary modes of transmission of CHV1?

A
  1. Contact with infected oral, nasal, or vaginal secretions of dam
  2. In-uterus transmission
  3. Passage through birth canal
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3
Q

What are two ways an older dog can get CHV1?

A
  1. Venereal

2. Contact with saliva, nasal discharge, or urine of infected dogs or puppies

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4
Q

What are 3 types of infections CHV1 can cause?

A
  1. In-utero infection
  2. Systemic neonatal infection
  3. CNS infection
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5
Q

What are two factors governing systemic neonatal infection from CHV1?

A
  1. Body temperature of puppies

2. Maternal immunity

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6
Q

What does feline herpesvirus 1 (FHV1) cause?

A

Feline rhinotracheitis

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7
Q

What is the main transmission routes of FHV1?

A
  1. Direct contact with infected cat
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8
Q

Where does virus replication of FHV1 primarily take place?

A

Mucosa of nasal septum, turbinates, nasopharynx and tonsils

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9
Q

What are some CS of feline rhinotracheitis caused by FHV1?

A
  1. Conjunctivitis
  2. Hyperemia and serous ocular discharge
  3. Ulcerative keratitis
  4. Severe necrohemmorrhagic rhinitis
  5. Multi focal necrohemorrhagic palatitis
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10
Q

T/F: oral ulcers are common in cats with FHV1 infection

A

False, oral ulcers are rare; common in FCV cats

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11
Q

What are 3 types of FHV1 and FCV vaccines available?

A
  1. MLV parenterally
  2. MLV intranasally
  3. Inactivated vaccine parenterally
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12
Q

What two infections do avian diseases cause?

A
  1. Infectious laryngotracheitis (Gallid herpesvirus 1)

2. Marek’ disease (Gallid herpesvirus 2)

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13
Q

What is the primary transmission of infectious laryngotracheitis (ILT) caused by GHV1?

A

Inhalation

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14
Q

T/F: the trigeminal ganglion is the target for ILT viral latency

A

True

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15
Q

What are the CS of severe ILT?

A
  1. Head shaking w/coughing
  2. “Pump handle respiration”
  3. Bloody mucous
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16
Q

T/F: The mild enzootic form of ILT is the most common while the severe epizootic is uncommon

A

True

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17
Q

Upon necropsy, was is an important finding in the trachea for ILT?

A

Tracheal plug (diphtheria membrane)

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18
Q

T/F: for ILT Dx, virus grows well is CAM of embryonated egg

A

True

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19
Q

What are 3 types of vaccines for ILT?

A
  1. CEO
  2. TCO
  3. Pox-vectored recombinant vaccine
20
Q

T/F: CEO vaccines against ILT have the capability to revert virulence and cause full blown ILT signs to induce better immunity

A

True

21
Q

T/F: TCO vaccines against ILT have similar effects

A

False; Given by eye drop only and does not spread significantly to revert virulence, limiting the level of induced immunity

22
Q

Merek’s disease is a very important disease in poultry caused by what herpesvirus?

A

Gallid herpesvirus 2

23
Q

What is the highly infection transmission route of Marek’s disease?

A

Cell free viruses released from feather follicles (labile)

24
Q

What is a less infectious route of transmission for Marek’s disease?

A

Viruses in dander (survive several months in poultry house dust or litter)

25
Q

What are the 4 pathotypes of Gallid herpes virus 2 that cause Marek’s disease (MD)?

A
  1. Mild (mMDV)
  2. Virulent (VMDV)
  3. Very virulent (vvMDV)
  4. Very virulent plus (vv+MDV)
26
Q

What are 4 overlapping virus-cell interactions observed in MD?

A
  1. Fully productive infection
  2. Productive-restrictive infection
  3. Non-productive infection
  4. Non-productive neoplastic transformation
27
Q

T/F: MD virus is slowly cytopathic and remains associated with cells

A

True

28
Q

What are 4 Clinical features of MD?

A
  1. Neurolymphomatosis
  2. Visceral lymphomatosis
  3. Ocular lymphomatosis
  4. Cutaneous lymphomatosis
29
Q

What are the CS of neurolymphomatosis caused by MD?

A
  1. Enlargement of nerve trunks
  2. Edematous, grey, or yellow look
  3. Lameness, droopy wings, paresis of legs
30
Q

What are some CS of visceral lymphomatosis caused by MD?

A
  1. Enlarged proventriculus, liver, ovary
31
Q

What are some CS of ocular lymphomatosis?

A
  1. Grating of iris

2. Partial to total blindness

32
Q

What are some CS of cutaneous lymphomatosis?

A
  1. Plucking of features

2. Enlarged feather follicles

33
Q

What is the most protective commercial vaccine available for MD?

A

CV1988/Rispens

34
Q

Inclusion body rhinitis is caused by what herpesvirus?

A

Porcine herpesvirus 2

35
Q

What are two transmission routes of inclusion body rhinitis caused by PHV2?

A
  1. Primarily inhalation

2. Transplacental

36
Q

What is the primary replication site for inclusion body rhinitis caused by PHV2?

A

Nasal mucous glands and epithelial cells of upper resp. tract

37
Q

What does inclusion body rhinitis caused by PHV2 look like histologically?

A

Infected cells enlarged with intranuclear inclusion bodies, especially in nasal glands

38
Q

What are the two most important viruses for malignant catarrhal fever (MCF)?

A
  1. Alcephaline herpesvirus-1 (AHV1) = wildebeest associated MCF
  2. Ovine herpesvirus-2 (OHV2) = sheep associated MCF
39
Q

T/F: AHV1 or wildebeest associated MCF is epizootic and seasonal

A

True

40
Q

T/F: Sheep associated MCF occurs year-round and is usually sporadic

A

True

41
Q

T/F: In Africa, MCF is found in cattle that are close to wildebeest, while outside Africa, usually associated with sheep contact

A

True

42
Q

T/F: cattle are dead end hosts for wildebeest or sheep associated MCF

A

True

43
Q

T/F: Diarrhea is rarely observed in sheep derived MCF and is more common is wildebeest derived MCF

A

False, more common in sheep associated MCF

44
Q

What are the early stage signs of head and eye MCF?

A
  1. Reddened eyelids
  2. Bilateral corneal opacity
  3. Crusty muzzle and nares
  4. Nasal discharge
  5. Salivation
45
Q

What are the later stage signs of head and eye MCF?

A

Erosions on tongue, hard palate, buccal papillae

46
Q

What is an important necropsy finding of MCF in cattle?

A

Zebra striping in colon

RUSVM Virology Exam 2 (10 decks)

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