Parturition Flashcards
What are the three stages of labor?
1) dilation of the cervix
2) expulsion of the fetus
3) expulsion if the placenta
Parturition?
Expulsion of the fetus and placenta from the uterus
What labor stage is the longest?
Stage one: dilation of the cervix
What are the 2 requirements for the expulsion of the fetus?
Myometrium contractions, dilation of the cervix
What hormones stimulate the myometrium contractions?
PGF-2a: contractions of myometrium and luteal regression
Oxytocin: myometrial cintractions itself and stimulates PGF production
Which hormones stimulate the dilation of the cervix?
Relaxin
PGF-2a
What three things occur in the stage of dilation of the cervix?
1) loss of collagen
2) loosening or separation of collagen fibers
3) stage of labor that takes the longest ad also associated with distocia
What two things comprise the endocrinology of parturition?
1) removal of the progesterone block
2) estrogen to progesterone ratio
What steps must take place for the progesterone block to be removed?
P4 blocks E2 receptor and oxytocin receptor formation and PGF synthesis. Removal of P4 permits receptor formation and PGF synthesis
A __ estrogen:progesterone ratio promotes myometrial excitability (contractions).
High
Ferguson reflex?
A neuroendocrine reflex in which the head of the fetus presses on cervix stimulating release of oxytocin from posterior pituitary gland
What is the ferguson reflex facilitated by?
A high E:P ratio
What is the function of oxytocin in the ferguson reflex?
Stimulate myometrial contractions and PGF release from uterus
Oxytocin receptors ___ 40-100 fold at term in women.
Increase
Oxytocin concentrations change little during ___ but increase greatly during ___.
Initial stages of labor
Expulsion of the fetus