part3

Question 1

With which one of the following cellular membranes is the nuclear envelope continuous:- a) ER, b) plasma membrane, c) peroxisomal membrane, d) nucleolar membrane?

Answer 1

Endoplasmic Reticulum

Question 2

In which mitochondrial sub-compartment are enzymes of the Kreb’s (citric acid) cycle found?

Answer 2

Mitochondrial Matrix

Question 3

The ribosomes are the main site of which one of the following cellular processes:- a) transcription, b) glycosylation, c) translation, d) phosphorylation?

Answer 3

Translation

Question 4

Which one of the following is the mitotic spindle a specialized form of:-
a) microtubule, b) microfilament, c) intermediate filament, d) nuclear envelope?

Answer 4

Microtubule

Question 5

Which one of the following does not receive any significant proteinaceaous contributions from the ER:- a) Golgi apparatus, b) lysosomes, c) mitochondria, d) plasma membrane?

Answer 5

Mitochondria

Question 6

Which one of the following receptors is found in the mitochondrial outer membrane:- a) TOM20, b) mannose-6-phosphate receptor, c) Pex5p, d) importin-alpha?

Answer 6

TOM20

Question 7

In immunofluorescence microscopy, what does the abbreviation FITC stand for?

Answer 7

Fluorescin Isothiocyanate

Question 8

Sedimentation rate density-gradient centrifugation separates organelles on the basis of which property?

Answer 8

Size

Question 9

Name two proteins that bind to b-catenin.

Answer 9

GSK, APC

Question 10

Which two of the following intermediate filament proteins can form heteropolymers:- a) keratins, b) lamins, c) vimentin, d) neurofilaments?

Answer 10

Keratins

Question 11

The transferrin receptor is involved in the uptake of which two of the following:-¬ a) cholesterol, b) antibodies, c) iron, d) some viruses?

Answer 11

Iron

Question 12

Name two adaptor proteins involved in clathrin-mediated endocytosis.

Answer 12

AP1, AP2,

Question 13

What is the most common post-translational modification found in signal transduction?

Answer 13

Phosphorylation

Question 14

Western blotting is used to detect which one of the following:- a) DNA, b) RNA, c) proteins, d) carbohydrates?

Answer 14

Protein

Question 15

Which channel property can be deduced from the value of the reversal voltage?

Answer 15

Specificity

Question 16

Which one of the following most accurately describes the quaternary structure of potassium channels:- a) monomeric, b) dimeric, c) tetrameric, d) octameric?

Answer 16

Tetrameric

Question 17

Which one of the following most closely approximates to the thickness of a phospholipid bilayer of the sort found in eukaryotic cells:- a) 60 nm, b) 6 nm,
c) 6 Å, d) 600 Å?

Answer 17

6nm

Question 18

What change in a membrane’s properties would you expect to see upon the incorporation of cholesterol or phospholipids containing fatty acyl chains with cis-double bonds?

Answer 18

Greater Fluidity

Question 19

Name one class of enzymes that hydrolyse phosphodiester bonds in phospholipids.

Answer 19

phospholipases

Question 20

Name the two ubiquitin ligases important in regulating the cell cycle.

Answer 20

APC/C and SCF

Question 21

Name the two cyclins that complex with CDK1 in mammalian cells.

Answer 21

Cyclin A and Cyclin B

Question 22

Which protein cleaves the cohesins that bind sister chromosomes together?

Answer 22

Separase

Question 23

Which class of proteases is activated during apoptosis?.

Answer 23

Caspase

Question 24

Name two proteins that are released from the mitochondria during apoptosis.

Answer 24

Cytochrome c, AIF (apoptotic inducing factor)

Question 25

Apart from motor neurons, which one of the following is other major cell type that is generated in the pMN domain in the spinal cord:- a) astrocytes, b) inter neurons, c) oligodendrocytes, d) macrophages?

Answer 25

oligodendrocytes

Question 26

Which one of the following is the major function of oligodendrocytes:-
a) specify cell fates, b) removal of excess neurotransmitters at synapses, c) myelinate axons, d) innervate target tissues?

Answer 26

myelinate axons