Part VIII Flashcards

1
Q

Where are peripheral chemoreceptors located?

A

aortic and carotid bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How much CO2 induces increase in ventilation?

A

20-30%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Are peripheral chemoreceptors responsive to CO2 or O2?

A

decreased O2 (hypoxia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The response to hypoxia is blunted if what falls as oxygen levels fall?

A

CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Are peripheral chemoreceptors responsive to CO2?

A

a little, but not the same as a decrease in oxygen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Peripheral chemoreceptors are altered by what?

A

CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When the SNS decreases flow to the peripheral chemoreceptors, what happens?

A

There is an increase in sensitivity to hypoxia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do we use the oxygen consumed after exercise?

A

to replenish oxygen stores and remove lactic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How much oxygen is stored in the body on a regular basis?

A

2L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where is the extra oxygen stored?

A

.2L in lungs, 1L with hemoglobin, .3L muscle myoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How fast is the oxygen store used during exercise?

A

2 minutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How much oxygen debt can the body reach?

A

11.5L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

After exercise, ventilation and oxygen uptake remain high until what?

A

oxygen is replaced

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is alactacid oxygen debt?

A

oxygen debt the first couple minutes post exercise to recondition the phosphagen system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is lactic acid oxygen debt?

A

oxygen debt that occurs over 40 minutes post exercise to remove the lactic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What causes extreme fatigue?

A

lactic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What decreases as you ascend?

A

barometric pressure

18
Q

What is normal PO2?

A

.21

19
Q

At how many feet will blood “boil”?

A

47mmHg

20
Q

What doesn’t change with altitude?

A

the concentration of oxygen

21
Q

What do u acclimatized people suffer from?

A

Deterioration of nervous system function

22
Q

What are the effects of hypoxia?

A

Sleepiness, false sense of well being, impaired judgement, clumsiness, blunted pain perception, decreased visual acuity, tremors, twitching, seizuers

23
Q

What can occur during acute mountain sickness?

A

Cerebral edema, pulmonary edema

24
Q

What is cerebral edema?

A

hypoxia + local vasodilation (systemic dilation)

25
Q

What is pulmonary edema?

A

hypoxia + local vasoconstriction (lungs constrict to get air to better areas)

26
Q

When exposed to low PO2 at high altitude, when does hypoxic stimulation of arterial peripheral chemorecetors?

A

immediately

27
Q

Are central chemoreceptors affected by hypoxia?

A

no, only increase in CO2

28
Q

What happens when you enter the hypoxic situation?

A

increased ventilation decreases CO2, which limits increase in ventilation as pH increases (respiratory alkalosis)

29
Q

What happens when increased ventilation decreases CO2?

A

it limits the increase in ventilation as pH increases (respiratory alkalosis)

30
Q

What happens when there is an increase in body pH?

A

inhibits ventilaiton and opposes the stimulatory effects of hypoxia on peripheral chemoreceptors

31
Q

What happens after being hypoxic because of high altitudes after a couple days?

A

ventilation increases 5x as inhibition fades because excretion of HCO3 by kidneys

32
Q

What happens when kidneys excrete HCO3?

A

it offsets decrease in CO2 to push pH back to normal. Now the hypoxic stimulation of chemoreceptors is no longer opposed by alkalosis and ventilation can increase 5 fold

33
Q

What happens during chronic mountain sickness?

A

increase in red cell mass, increase pulmonary arterial blood pressure, enlarged right ventricle, decreased TPR, congestive heart failure, death if person is not removed to lower altitude

34
Q

Why is an increase in red blood cell mass bad?

A

thicker blood, less O2 available, increased carrying capacity to better get O2 to tissues

35
Q

What happens when people are acclimatized?

A
great increase in pulmonary ventlation
increase in RBCs
increase diffusing capacity of lungs
increase tissue vascularity
increase ability of tissues to use O2
increased synthesis of 2,3DPG
36
Q

What does increase synthesis of 2,3 DPG do?

A

shifts oxy-hemoglobin dissociation curve to right, which is an advantage to the tissues, but not to the lungs

37
Q

Where is there an incrase ability of tissues to use oxygen?

A

slight increase cell mitochondria

slight increase in cellular oxidative systems

38
Q

What is different about people who have natural acclimization?

A

high rate of ventilatory capacity compared to body mass
increase size of right ventricle
shift in oxy-hemoglobin dissociation curve

39
Q

What is hyperbarism?

A

when pulmonary capillary blood is exposed to extremely high alveolar gas pressures

40
Q

Can the high pressures under the sea be lethal?

A

yes