Parkinsons - NF Flashcards
Parkinsons symptoms -6
Akinesia Bradykinesia Resting tremor Loss of postural reflexes Depression Constipation
Dopamine making pathway
Tyrosine
L dopa
Dopamine
Tyrosine to L dopa enzyme
Tyrosine hydroxylase
L dopa to dopamine enz
L dopa carboxylase
PARK2 cause
Mutation in PARKIN gene
Miss form of E2 ubiquitin protein ligase
E2 normally ubiquitinases alpha synuclein
Markes it for degredations
PARK2 found in
Juvenile form - early 20s
Autosomal recessive, slow progressions
Autosomal recessive PD
PARK2
PARK6
PARK6 cause
Mutation in PINK1
What does PINK do
Phosphorylates PARKIN, allowing the destruction of a synuclein
What is mitophagy
Breaking down broken mitochondira
Mutations associated with mitophagy
PINK1 and PARKIN
Autosomal dominant Parkinsons
PARK1
PARK4
PARK8
What is PARK1
Early onset
a synuclein mutation
causes it to become aggregated
What do a synuclein accumations cause
Lewy bodies that damage cells
PARK4 causes
early onset
a synuclein triplication
Get 4 functioning copies which agreegate
PARK8 mutations in
LRRK2 - Leucine rich repeat kinase
Environmental factors in PD
Post encephalitis MPTP Neurotoxins such as rotenone, paraquat CO poisoning Traumatic injury to head and repetitive Stroke
What nACh subunits can drive dopamine release
a6 b2 (found in dopaminergic neurons and terminals) and a4 b2
