Parkinsons - NF

Question 1

Parkinsons symptoms -6

Answer 1

Akinesia
Bradykinesia
Resting tremor
Loss of postural reflexes
Depression
Constipation

Question 2

Dopamine making pathway

Answer 2

Tyrosine
L dopa
Dopamine

Question 3

Tyrosine to L dopa enzyme

Answer 3

Tyrosine hydroxylase

Question 4

L dopa to dopamine enz

Answer 4

L dopa carboxylase

Question 5

PARK2 cause

Answer 5

Mutation in PARKIN gene
Miss form of E2 ubiquitin protein ligase
E2 normally ubiquitinases alpha synuclein
Markes it for degredations

Question 6

PARK2 found in

Answer 6

Juvenile form - early 20s

Autosomal recessive, slow progressions

Question 7

Autosomal recessive PD

Answer 7

PARK2

PARK6

Question 8

PARK6 cause

Answer 8

Mutation in PINK1

Question 9

What does PINK do

Answer 9

Phosphorylates PARKIN, allowing the destruction of a synuclein

Question 10

What is mitophagy

Answer 10

Breaking down broken mitochondira

Question 11

Mutations associated with mitophagy

Answer 11

PINK1 and PARKIN

Question 12

Autosomal dominant Parkinsons

Answer 12

PARK1
PARK4
PARK8

Question 13

What is PARK1

Answer 13

Early onset
a synuclein mutation
causes it to become aggregated

Question 14

What do a synuclein accumations cause

Answer 14

Lewy bodies that damage cells

Question 15

PARK4 causes

Answer 15

early onset
a synuclein triplication
Get 4 functioning copies which agreegate

Question 16

PARK8 mutations in

Answer 16

LRRK2 - Leucine rich repeat kinase

Question 17

Environmental factors in PD

Answer 17

Post encephalitis
MPTP
Neurotoxins such as rotenone, paraquat
CO poisoning
Traumatic injury to head and repetitive
Stroke

Question 18

What nACh subunits can drive dopamine release

Answer 18

a6 b2 (found in dopaminergic neurons and terminals) and a4 b2