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neuropharm > nACh R > Flashcards

nACh R Flashcards

1
Q

Where does the cholinergic supply to cerebral cortex come from

A

Basal nucleus of Meynert

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2
Q

What supplies the hippocampus with ACh

A

Septal nuclei

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3
Q

How many subunits make up a nACh R

A
  1. They are pentamers
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4
Q

What subtypes are found in muscles

A

a1, b1, y, delta, E

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5
Q

What subtypes are found in neurons

A

a2-a10

b2, b3, b4

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6
Q

What subunit combos are common in autonomic ganglia

A

a3 b4

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7
Q

What are the most common combos in the CNS

A

a2 b4

a7

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8
Q

What is a selective a7 blocker

A

a-bungarotoxin

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9
Q

What is the conductance of a7 like

A

Fast activating
high Ca entry
Fast desensitisation

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10
Q

a2 b4 conductuctance

A

Slow activation
Low Ca entry
Slow desensitisation

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11
Q

How many TMD in each subunit

A

4

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12
Q

a2 b4 selective antagonist

A

DH beta E

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13
Q

nACh locations

A

Presynaptcial to cause NT release by Ca entry

Postsynatpic to cause EPSP (especially in periphery)

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14
Q

nACh and epilepsy

A

Point mutations cause ADNFLE

Autosomal dominant nocturnal frontal lobe epilepsy

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15
Q

nACh schizophrenia

A

a7 proposed as therapuetic target

High prevalance of smokers in schiz, so likely that nicotine helps

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16
Q

Dopamine reward pathways

A

a4 and b2 are required for nicotine induced released on dopamine in the brain - found presynaptically

17
Q

What diseases are assocaited with nACh

A 
Epileisy
Parkinsons
ALZHIEMERS
neuopathic pain
nictotine addiction
18
Q

How is nicotine addictive

A

a7 found on presynaptic glutamate spines. Stimulation of this causes more gulatmate release, wwhich excites dopaminerigc neruons in VTA. this causes more DA release to NAc and PFC, = reward

19
Q

Smoking cessation therapies

A

Nicotine replacement

Varenicline (partial agonsit at a4 b2, competes with it)

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