nACh R Flashcards
Where does the cholinergic supply to cerebral cortex come from
Basal nucleus of Meynert
What supplies the hippocampus with ACh
Septal nuclei
How many subunits make up a nACh R
- They are pentamers
What subtypes are found in muscles
a1, b1, y, delta, E
What subtypes are found in neurons
a2-a10
b2, b3, b4
What subunit combos are common in autonomic ganglia
a3 b4
What are the most common combos in the CNS
a2 b4
a7
What is a selective a7 blocker
a-bungarotoxin
What is the conductance of a7 like
Fast activating
high Ca entry
Fast desensitisation
a2 b4 conductuctance
Slow activation
Low Ca entry
Slow desensitisation
How many TMD in each subunit
4
a2 b4 selective antagonist
DH beta E
nACh locations
Presynaptcial to cause NT release by Ca entry
Postsynatpic to cause EPSP (especially in periphery)
nACh and epilepsy
Point mutations cause ADNFLE
Autosomal dominant nocturnal frontal lobe epilepsy
nACh schizophrenia
a7 proposed as therapuetic target
High prevalance of smokers in schiz, so likely that nicotine helps
Dopamine reward pathways
a4 and b2 are required for nicotine induced released on dopamine in the brain - found presynaptically
What diseases are assocaited with nACh
Epileisy Parkinsons ALZHIEMERS neuopathic pain nictotine addiction
How is nicotine addictive
a7 found on presynaptic glutamate spines. Stimulation of this causes more gulatmate release, wwhich excites dopaminerigc neruons in VTA. this causes more DA release to NAc and PFC, = reward
Smoking cessation therapies
Nicotine replacement
Varenicline (partial agonsit at a4 b2, competes with it)
