Calcium channels in disease Flashcards
Pain: What channels and subunits are associated with it
N type
T type
Alpha 2 delta
N type role in pain + drug
Become enhanced after nerve injury
Ziconotide provides relief from chronic pain
T type in pan (subtype)
Ca v 3.2
Expressed predominantly in DRG
Ca v 3.2 knockdown shows analgesia
alpha 2 delta in pain
Mice that overexpress a2delta-1 show hypersensitivity
KO mice show opposite
what drugs bind to alpha deta
Gabapentin
Pregabalin binds to the same site with higher affinity
Type associated with epilepsy
T type
What drugs block t tpye for epilepsy
Ethosuximide
Phenytoin
Carbamezpine
Why are t types associated with epilepsy
Low voltage activated, so become activated near resting potential
This helps to determine firing frequency by allowing ions through
Where in neurons are key for Parkinsons
Substantia nigra
What Ca channels cause pacemaker activity in SN
L type (Ca v 1.3)
How can pacemaker contribute for Parkinsons
Higher Ca levels cause excitotoxicity and damage
What calcium drugs are being developed for Parkinsons
L tpye blockers
Nifedipine and verapamil
What gene mutation causes Fragile X syndrome
FMR1
What protein does FMR1 gene code
FMRP
What does FMRP interact with
Ca v 2.2, modulates activity
