Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuropharm > Calcium Channels > Flashcards

Calcium Channels Flashcards

1
Q

Overall structure of channels

A

Alpha 1 subunit forms TM pore.
Alpha 2 delta is extracellular unit
Beta is intracellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Alpha 1 subunit structure

A

4 TM domains, each with S1-S6 units.
S4 is voltage sensor
Between S5 and S6 is Ca2+ selective filter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Beta subunit

A

4 isoforms B1-B4
Binds to alpha domain
Enhances trafficking of alpha to membrane
Increases current amplitude and shift activation Ca entry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Alpha 2 delta

A

Enhances trafficking of alpha.

Delta part anchors to membrane, Alpha 2 is extracellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where does Gabapentin bind to?

A

Alpha 2 delta subunit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

L type activation threshold

A

High

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

L type subtypes

A

Ca v 1.1 - 1.4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

L type blocked by

A

Nifedipine, Verapamil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

N type

A

High activation threshold, Main source for nerve terminal transmitter release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

N type irrevesibly blocked by

A

w-conotoxin GV1A (irreversibly blocks pores). From cone shell mollusc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Drug used to block N type

A

Ziconotide. Used for neuropathic pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

P/Q type function

A

Nerve terminal transmitter release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

P/Q type blocked by

A

w-Agatoxin IVA. From funnel web spider, activation gating inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where are R type found

A

Neurons and dendrites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

R type blocked by

A

SNX-482, from Tarantulas. Activation gating inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

T type function and found

A

Low voltage activated, fast inactivation, Found in cardiac pacemakers ad well as in the brain

17
Q

T type numbers and location

A
  1. 1 - Neuronal, cardiac
  2. 2 - Neuronal
  3. 3 - Neuronal
18
Q

T type selectively blocked by

A

mibefradil

19
Q

Other T type blockers - 4

A

Carbamazepine, phenytoin also block Na channels
Ni 2+ blocks Ca v 3.2 selectively
Ethosuximide - also blocks Na channels
TTA-A2, TTA-P2 - Novel ones

Neuropharm (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions