Monoamines Flashcards
All monoamine transporters are GPCR except which
5HT 3
Pathway to Adrenaline from precursor
Phenylalanine Tyrosine L dopa Dopamine Noradrenaline Adrenaline
What does MOA-A break down (3)
Serotonin
NA
Adrenaline
What does MAO-B breakdown
Phenylethylamine
Benzylamine
MAO-A/B breakdown
Dopamine
Tryamine
Tryptamine
What does COMT breakdown
Dopamine
What receptros are in D1 like family
D1
D5
What recepotors are in D2 family
D2
d3
d4
What do D1 family couple
Gs
Increase cAMP
What do D2 like couple
Gi/o
Decrease cAMP
Activation of K channels
Dopamine functions
Blood vessel vasodilation GI tract motility Insulin production Sodium excretion in kidney CNS motor control/reward
What is alpha 1 adrenoreceptor coupled to
Gq
What is a2 adreno coupled to
gi/o
What are Beta adrenorectpor coupled to
Gs
Serotonin fuctions
GI motilily Pain modulation Sleep/wake Nausea and appetite Memory and learning Mood and fear
ADHD features
Inattention
Hyperactivity
Impulsive behaviour
ADHD treatment
Methylphenidate (ritalin)
Atomoxetine
Methylphenidate mechanisms
targets NA/DA transporter
Increases theri levels in PFC
Atomoxetine
Non stimulant
NA reuptake inhibitor
What does Phentermine udo
Stimulates NA release in hypothalamus and NAc
What is phentermine used for
Weight loss
