GABA A Flashcards
1
Q
How is GABA made
A
Glutamate altered by GAD (glutamic acid decarboxylase)
2
Q
GABA transporter on nerve terminals
A
GAT1
3
Q
GABA transporter on astrocytes
A
GAT3
4
Q
GABA transport blocker
A
Tiagabine
5
Q
GABA destoyed by
A
GABA transaminase
6
Q
GABA-Tranaminase blokcer
A
Vigabatrin
7
Q
GABA A structure
A
Pentamer, subunits a, b, y, d, e
Each subunit has 4TM
8
Q
What ions do gaba A let through
A
Cl-
HCO3-
9
Q
Most common arrangement of subunits in receptor
A
a, b, a, b, y/d/e
10
Q
Which subunits do GABA bind in between
A
a and b. 2 GABA needed
11
Q
Where do benzos bind
A
BEtween a and y
12
Q
How much gaba is release per synapse
A
1-3 mmol
