Parkinsons

Question 1

patho of parkinsons

Answer 1

• loss of substantia nigra

Question 2

epi of parkinsons

Answer 2

after age 50

Question 3

Dx of parkinsons

Answer 3

clincal Dx

Question 4

clinical features of parkinsons

Answer 4

1. pill rolling at rest
2. brady kinesia
3. cogwheel rigidity
4. poor postural reflexes
5. masked face
6. dysarthia and dysphagia
7. impared cog. function as advances
8. autonomic dysfunction

Question 5

8 Tx for parkinsons

Answer 5

1. L-dopa/carbidopa
2. dopa-r agonsist
   - pergolide
   - bromocriptine
   - may prevent use of L-dopa for years
3. selegline
   - inhibits MOA B activity
4. amantidine
   - increases avail of endogenous dopa
5. antichol
6. amytriptiline
7. surgery
   - deep brain stim