Multiple myeloma

Question 1

patho of MM

Answer 1

prolif. of a single plasma cell causing many copies of a single Ig (usually IgG or IgM)

Question 2

epi of MM

Answer 2

after 50 and more blacks

Question 3

main clinical features

Answer 3

CARB - I
Calcemia
Anemia - normocytic
Renal
- Ig precipitaiton in tubules
- bence jones protein in urine
Bone pain
- osetolytic lesions, fractures and vert. collapse
- loss of height due to vert fractures
Infection
- most common cause of death

Question 4

4 tests for MM

Answer 4

1. Serum and urine electrophoresis
   - monoclonal spike of single Ig
2. plain films
   - lytic lesions
3. bone marrow biopsy
   - abnormal cells
4. Serums
   - hyperCa
   - increased proteint
   - RBCs in rouleux formation (stacked)

Question 5

Tx for MM

Answer 5

for Sx only

1. Chemo
2. rads for pain
3. transplant - autologous preferred

Question 6

what is MGUS

Answer 6

monoclonal gamopathy of unknown sig

Question 7

feat of MGUS

Answer 7

• common in elderly
• usually aSx
• risk of dev. into MM