Coag issues Flashcards
1
Q
what is von willebrand dis
A
- auto dom cauing lack of VWF
- most common bleeding disorder
- vWF enhances platelet agg and adhesion
2
Q
3 main clinical feat
A
- cut and mucosal bleeds
- mennorhagia
- GI bleeds
3
Q
Dx findings
A
prolonged bleed times, normal platelets PTT may be up
4
Q
Tx of VWD
A
- DDVAP - causes endothelial excretion of VWF
- factor 7 concentrates
- avoid aspirin/NSAIDS
5
Q
what is hemophlia A
A
X linked
- def. in factor 8
- amount of bleed depends on how much factor
6
Q
5 features of hemo A
A
- hemarthrosis
- knees most common
- can cause destruciton - intracranial bleeds
- intramuscular hematoma
- retroperitoneal hematoma
- hematuria or hematospermia
7
Q
Dx of hemo A
A
- long PTT
2. low factor 8 levels
8
Q
what does PT (INR) and PTT measure
A
PT and INR - extrinsic and common
PTT - intrinsic and common
9
Q
Tx of hemo A
A
- arthrosis
- analgesia
- immobilize - clotting factor replacement
- factor replacement
- not FFP and cryoprecipitate - DDVAP can help
10
Q
what is hemo B
A
X linked
- loss of factor 9
otherwise the same as A
11
Q
what is DIC
A
abnormal activation of caog leading to microthrombi throughout the system
- comsumes platelets, fibrin, and coag factors
- fibrinolytic mech are activated so get bleeding and thrombosis at same time
12
Q
causes of DIC
A
- infections
- most common, esp gr neg sepsis - obstetric complications
- major tissue injury
- malig. - lung, pancreas, prostate, GI, myelocytic leukemia
- shock
13
Q
clin features of DIC
A
- bleeding tendency
- espcialyl when acute - thrombosis
- can get infarcts
14
Q
Dx of DIC
A
increased - PT, PTT, INR, bleed times, D-dimer
decreased - platelets, fibrinogen
15
Q
Tx of DIC
A
manage issue causing
support
- FFP
- platelet transfusions
