Parasympathetic Autonomics Flashcards
M3 and M2 receptors - sphincter muscle of iris
contraction (miosis)
M3 and M2 receptors - ciliary muscle of eye
contraction for near vision
M3 and M2 receptors - lacrimal glands of eye
increased secretion
M2 receptor - SA node
decreased HR
M2 receptor - atria of heart
decreased contractility and shortened AP duration
M2 receptor - AV node
decrease in conduction velocity, AV block
M2 receptor - His-purkinje system
little effect
M2 receptor - ventricles of heart
slight decrease in contractility
muscarinic receptors - blood vessels
no innervation
M3 receptor - endothelium
activation of NO synthase
M3 and M2 receptors - tracheal and bronchial smooth muscle
contraction
M3 and M2 receptors - bronchial glands
stimulation
M3 and M2 receptors - motility and tone of stomach and intestines
increased
M3 and M2 receptors - sphincters of stomach and intestines
relaxation
M3 and M2 receptors - secretions in stomach and intestines
stimulation
M3 receptor - detrusor muscle of bladder
contraction
M3 receptor - trigone and sphincter of bladder
relaxation
M3 and M2 receptors - salivary glands
increase potassium and water secretion
M1 receptors
- location
- what GCPR
- mechanism
- nerves
- Gq
- IP3 and DAG cascade
M2 receptors
- location
- what GCPR
- mechanism
- heart, nerves, smooth muscle
- Gi
- inhibition of cAMP and activation of K+ channels
M3 receptors
- location
- what GCPR
- mechanism
- glands, smooth muscle, endothelium
- Gq
- IP3 and DAG cascade
M4 receptors
- location
- what GCPR
- mechanism
- CNS
- Gi
- inhibition of cAMP
M5 receptors
- location
- what GCPR
- mechanism
- CNS
- Gq
- IP3 and DAG cascade
NN receptors
- location
- mechanism
- postganglionic cell body, dendrites, CNS
- Na+, K+ depolarizing ion channel
