Antiadrenergic Drugs Flashcards
effect of alpha antagonists on genitourinary system
- relaxation of smooth muscle in prostate
- decreased resistance to flow of urine
what cardiac arrhythmias can be treated with beta blockers
- a flutter and a fib
- ventricular ectopic beats
effects of beta blockers on eye
reduce production of aqueous humor –> reduces intraocular pressure
adverse effects of alpha antagonists
- postural hypotension
- tachycardia
- retention of fluid and salt
- impaired ejaculation
- nasal stuffiness
if pt is having hypoglycemic episodes, instead of a beta blocker what should you switch to
beta1-selective
effect of alpha antagonists on cardiovascular system
- decreased peripheral vascular resistance
- decreased BP
- postural hypotension
- reflex tachycardia
adverse effects of beta blockers on the CNS system
- what drug should you switch to?
- sedation
- sleep disturbances
- depression
–> switch to more hydrophilic drug
effect of alpha antagonists on eye
- relaxation of pupillary dilator muscle - miosis (constricted pupils)
are beta blockers indicated in acute congestive heart failure
no
effects of beta blockers on respiratory system
increase airway resistance
what beta blockers are used to treat chronic heart failure
- metoprolol
- carvedilol
effects of beta blockers on blood vessels
- initial rise in PVR
- chronic use –> decrease in PVR (lowers BP in hypertensive pts)
what alpha antagonist would you use to treat BPH
tamsulosin
(greater selectivity for alpha1A than alpha1B)
- alpha1A is the most important alpha receptor subtype mediating prostate smooth muscle contraction
what alpha antagonists would you use to treat chronic (essential) hypertension
prazosin doxazosin (both alpha1 selective)
effects of beta blockers on cardiovascular system
- negative inotropic effect
- negative chronotropic effect
- slow AV node conduction