Cholinergic Drugs Flashcards
clinical use of acetycholine
intraocular use during surgery to cause miosis (pupil contraction)
clinical use of bethanechol
urinary retention and heartburn
clinical use of carbachol
treatment of glaucoma or to produce miosis during surgery or ophthalmic examination
clinical use of cevimeline
treat dry mouth (xerostomia) in pts with Sjogren’s
clinical use of pilocarpine
xerostomia tx in pts with Sjogren’s or head and neck cancer treatment related to xerostomia, miosis during ophthalmic procedures, and for glaucoma
clinical use of varenicline
smoking cessation
adverse effects of varencline
neuropsychiatric symptoms like change in behavior, agitation, depressed mood, suicidal ideation, and attempted or completed suicide
toxicity effects of muscarinic stimulants
- N/V/D
- urinary urgency
- salivation
- sweating
- cutaneous vasodilation
- bronchial constriction
- increase in glandular secretion
- (SLUDGE)
in what patients are muscarinic stimulants contraindicated
pts with:
- asthma
- hyperthyroidism
- coronary insufficiency
- acid-peptic disease
toxicity effects of nicotinic stimulants
- nicotine poisoning from cigarettes and insecticides
- CNS stimulation
- skeletal muscle end plate depolarization
- respiratory paralysis
- HTN
- cardiac arrhythmias
what to give pts suffering from toxicity of direct-acting cholinergic agonists
atropine and parenteral anticonvulsants (diazepam)
describe how cholinergic agonists help glaucoma
stimulation of mAChRs on ciliary body facilitates aqueous humor
