Paralytic Agents Drugs

Question 1

Succinylcholine (depolarizing)

Answer 1

MOA: acetylcholine agonist, binds to nicotinic receptor at the neuromuscular junction

Stimulates the muscle so much that it causes muscle paralysis

There is no reversal medication. You will have to ventilate until drug is metabolized

Contraindication: pregnancy, MG (the drugs for mg are the opposite of paralytic)

Side effects: hyperkalemia

Adverse effect: respitory depression , apnea
Malignant hyperthermia (if this happens give dantrolene )

Question 2

Vercuronium (non depolarizing )

Answer 2

MOA: competitive antagonist ( binds to ACh receptors without inducing the effect of ACh ) which can bring paralysis because it is blocking acetylcholine

Side effect: histamine release leading to rash, hives angiodema, bronchospasm, low BP, tachycardia

Must use REVERSAL AGENT NEOSTIGMINE